A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)
Launched by BRISTOL-MYERS SQUIBB · Sep 21, 2022
Trial Information
Current as of July 27, 2025
Recruiting
Keywords
ClinConnect Summary
The SUCCESSOR-2 trial is studying a new treatment for patients with relapsed or refractory multiple myeloma, a type of blood cancer. This trial is comparing a combination of three medications: Mezigdomide, carfilzomib, and dexamethasone against just carfilzomib and dexamethasone. The goal is to see if adding Mezigdomide can help patients whose cancer has returned or hasn’t responded to previous treatments.
To join this study, participants need to have a confirmed diagnosis of multiple myeloma and measurable disease, meaning their cancer can be tracked with specific tests. They should have already tried at least one treatment for their cancer, including lenalidomide and an anti-CD38 monoclonal antibody. Participants will need to meet certain health criteria, but those who have not had prior treatment with the medications being studied are not eligible. If you choose to participate, you will receive regular medical care and monitoring throughout the trial, helping researchers understand how well the new treatment works and if it is safe.
Gender
ALL
Eligibility criteria
- • Inclusion Criteria
- • - Participant has documented diagnosis of multiple myeloma and measurable disease, defined as any of the following:.
- • i) Myeloma-protein (M-protein) ≥ 0.5 grams/deciliter (g/dL) by serum protein electrophoresis (sPEP), or.
- • ii) M-protein ≥ 200 milligrams (mg)/24-hour urine collection by urine protein electrophoresis (uPEP) or,.
- • iii) For participants without measurable disease in sPEP or uPEP: serum free light chain levels \> 100 mg/liter (L) (10 mg/dL) involved light chain and an abnormal κ/λ free light chain ratio.
- • Participant has received at least one prior line of anti-myeloma therapy. Note: One line can contain several phases (e.g., induction, \[with or without\] hematopoietic stem cell transplant, (with or without) consolidation, and/or \[with or without\] maintenance therapy).
- • Participant must have received prior treatment with lenalidomide and at least 2 cycles of an anti-CD38 monoclonal antibody (mAb) (participants who were intolerant of an anti-CD38 mAb and received \< 2 cycles are still eligible).
- • Participant achieved minimal response or better to at least 1 prior anti-myeloma therapy.
- • Participant must have documented disease progression during or after their last antimyeloma regimen.
- • Exclusion Criteria
- • Participant who has had prior treatment with mezigdomide or carfilzomib.
- • Participant has previously received allogeneic stem cell transplant at any time or received autologous stem cell transplant within 12 weeks of initiating study treatment.
- • Other protocol-defined Inclusion/Exclusion criteria apply.
About Bristol Myers Squibb
Bristol-Myers Squibb (BMS) is a global biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines that help patients prevail over serious diseases. With a robust portfolio of products across multiple therapeutic areas, including oncology, immunology, cardiovascular, and fibrotic diseases, BMS emphasizes cutting-edge research and a commitment to advancing medical science through clinical trials. The company is driven by a mission to provide transformative therapies, leveraging collaboration and scientific expertise to address unmet medical needs and improve patient outcomes worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bronx, New York, United States
Adelaide, South Australia, Australia
Annapolis, Maryland, United States
Vejle, , Denmark
Boston, Massachusetts, United States
Houston, Texas, United States
Columbus, Ohio, United States
Boise, Idaho, United States
Norfolk, Virginia, United States
Camperdown, New South Wales, Australia
Tacoma, Washington, United States
Minneapolis, Minnesota, United States
Vancouver, Washington, United States
Atlanta, Georgia, United States
Gosford, New South Wales, Australia
Wuerzburg, , Germany
St Leonards, New South Wales, Australia
Heidelberg, Victoria, Australia
Mumbai, Maharashtra, India
Kashiwa, Chiba, Japan
Sapporo, Hokkaido, Japan
Leipzig, , Germany
Glasgow, , United Kingdom
Melbourne, Victoria, Australia
Nashville, Tennessee, United States
Sydney, New South Wales, Australia
Taichung, , Taiwan
Tainan, , Taiwan
Augusta, Georgia, United States
Patras, , Greece
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Madrid, , Spain
Kanazawa, Ishikawa, Japan
Tokyo, , Japan
Camperdown, , Australia
Athens, , Greece
Barcelona, , Spain
Halifax, Nova Scotia, Canada
Birmingham, , United Kingdom
Seoul, , Korea, Republic Of
Chiba, , Japan
Valencia, , Spain
Roskilde, , Denmark
Changchun, Jilin, China
Chapel Hill, North Carolina, United States
Kumamoto, , Japan
Nagoya, Aichi, Japan
Fukuoka, , Japan
Okayama, , Japan
Taunton, , United Kingdom
Cleveland, Ohio, United States
Düsseldorf, , Germany
Jena, , Germany
Mobile, Alabama, United States
Nürnberg, Bayern, Germany
Chuo, Yamanashi, Japan
Shenyang, Liaoning, China
Toronto, Ontario, Canada
Kyoto, , Japan
Kamakura, Kanagawa, Japan
Irvine, California, United States
Wuxi, Jiangsu, China
Nanchang, Jiangxi, China
Shenyang, Liaoning, China
Budapest, , Hungary
Taipei, , Taiwan
Leeds, , United Kingdom
Whittier, California, United States
Houston, Texas, United States
Lecce, , Italy
Wien, , Austria
Zhengzhou, Henan, China
Madrid, , Spain
San Cristobal De La Laguna, Santa Cruz De Tenerife, Spain
Pisa, , Italy
Nantong, Jiangsu, China
Suzhou, Jiangsu, China
Roanoke, Virginia, United States
Saint Petersburg, Florida, United States
Tokyo, , Japan
Chattanooga, Tennessee, United States
Guangzhou, Guangdong, China
Changsha, Hunan, China
Debrecen, , Hungary
Beijing, Beijing, China
Nanjing, Jiangsu, China
Gurgaon, Haryana, India
Jerusalem, , Israel
Jena, Thüringen, Germany
Debrecen, Hajdú Bihar, Hungary
Fort Worth, Texas, United States
Chandigarh, , India
Enschede, , Netherlands
Pécs, Baranya, Hungary
Los Angeles, California, United States
Changchun, Jilin, China
Shanghai, Shanghai, China
Changsha, Hunan, China
West Palm Beach, Florida, United States
Koshigaya, Saitama, Japan
Plovdiv, , Bulgaria
Osaka, , Japan
Providence, Rhode Island, United States
Marshfield, Wisconsin, United States
Linz, , Austria
Bucuresti, , Romania
Koto, Tokyo, Japan
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Budapest, , Hungary
Fort Myers, Florida, United States
Milano, Lombardia, Italy
Rozzano, Milano, Italy
Temple, Texas, United States
Fukuoka, , Japan
San Miguel De Tucumán, Tucumán, Argentina
New Delhi, Delhi, India
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Kaohsiung, , Taiwan
Beijing, Beijing, China
Aarhus, Midtjylland, Denmark
Budapest, , Hungary
Hangzhou, Zhejiang, China
Nyiregyhaza, Szabolcs Szatmár Bereg, Hungary
Charleston, South Carolina, United States
Odense, Syddanmark, Denmark
Thessaloniki, Thessaloníki, Greece
Athens, Attikí, Greece
Morgantown, West Virginia, United States
Zerifin, , Israel
Singapore, Central Singapore, Singapore
Singapore, Central Singapore, Singapore
Stavanger, Rogaland, Norway
Oslo, , Norway
Rosario, Santa Fe, Argentina
Dresden, , Germany
Atlanta, Georgia, United States
Patras, Achaḯa, Greece
Sofia, , Bulgaria
Xi'an, Shaanxi, China
Worcester, Massachusetts, United States
Kiel, Schleswig Holstein, Germany
Bengaluru, Karnataka, India
Hyderabad, Telangana, India
Barcelona, Barcelona [Barcelona], Spain
Shiwa Gun Yahaba Cho, Iwate, Japan
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
L'hospitalet Del Llobregat, Barcelona [Barcelona], Spain
Madrid, Madrid, Comunidad De, Spain
East Melbourne, Victoria, Australia
Wuhan, Hubei, China
Zerifin, Hamerkaz, Israel
Holon, Hamerkaz, Israel
Rio De Janeiro, , Brazil
Tianjing, Tianjin, China
Valencia, Valenciana, Comunitat, Spain
Rio De Janeiro, , Brazil
Bergen, Hordaland, Norway
Chennai, Tamil Nadu, India
Rosario, Santa Fe, Argentina
Buenos Aires, , Argentina
Ciudad Autónoma De Buenos Aires, , Argentina
Córdoba, , Argentina
Brisbane, Queensland, Australia
Bendigo, Victoria, Australia
Gosford, , Australia
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Fuzhou, Fujian, China
Guangzhou, Guangdong, China
Zhengzhou, Henan, China
Changsha, Hunan, China
Changsha, Hunan, China
Nantong, Jiangsu, China
Suzhou, Jiangsu, China
Wuxi, Jiangsu, China
Changchun, Jilin, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Xi'an, Shaanxi, China
Jinan, Shandong, China
Shanghai, Shanghai, China
Tianjin, Tianjin, China
Kunming, Yunnan, China
Hangzhou, Zhejiang, China
Taiyuan, , China
Medellin, Antioquia, Colombia
Valledupar, Cesar, Colombia
Bogota, Cundinamarca, Colombia
Cali, Valle Del Cauca, Colombia
Leipzig, Saxony, Germany
Hong Kong, , Hong Kong
New Delhi, Delhi, India
Gurgaon, Haryana, India
Bengaluru, Karnataka, India
Mumbai, Maharashtra, India
Chennai, Tamil Nadu, India
Hyderabad, Telangana, India
Hyderabad, Telangana, India
Kolkata, West Bengal, India
Thane, , India
Singapore, Central Singapore, Singapore
Singapore, Central Singapore, Singapore
Kaohsiung City, Kaohsiung, Taiwan
Kaohsiung, , Taiwan
Taipei, , Taiwan
Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan
Breda, Noord Brabant, Netherlands
Madrid, , Spain
Sao Paulo, São Paulo, Brazil
London, Ontario, Canada
Little Silver, New Jersey, United States
Charlotte, North Carolina, United States
Tacoma, Washington, United States
Salvador, Bahia, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Sao Paulo, São Paulo, Brazil
São Paulo, , Brazil
Tianjin, Tianjin, China
Copenhagen, Hovedstaden, Denmark
Thane, Maharashtra, India
Rozzano, Milano, Italy
Stavanger, Rogaland, Norway
San Cristobal De La Laguna, Santa Cruz De Tenerife, Spain
Halifax, Nova Scotia, Canada
Toronto, Ontario, Canada
Montreal, Quebec, Canada
Bologna, , Italy
Taipei, , Taiwan
Badalona, Barcelona [Barcelona], Spain
Enschede, , Netherlands
Lecce, , Italy
São Paulo, , Brazil
Camperdown, New South Wales, Australia
Berlin, , Germany
Valledupar, Cesar, Colombia
Cerritos, California, United States
Ciudad Autónoma De Buenos Aires, Buenos Aires, Argentina
Abb, Ciudad Autónoma De Buenos Aires, Argentina
St Leonards, New South Wales, Australia
Sydney, New South Wales, Australia
Adelaide, South Australia, Australia
Heidelberg, Victoria, Australia
Melbourne, Victoria, Australia
Linz, Oberösterreich, Austria
Wien, , Austria
Wien, , Austria
Rio De Janeiro, , Brazil
Fuzhou Fujian, Fujian, China
Fuzhou Fujian, Fujian, China
Nanjing, Jiangsu, China
Cali, Valle Del Cauca, Colombia
Aarhus, Midtjylland, Denmark
Roskilde, Sjælland, Denmark
Odense, Syddanmark, Denmark
Vejle, Syddanmark, Denmark
Kiel, Schleswig Holstein, Germany
Berlin, , Germany
Heidelberg, , Germany
Köln, , Germany
Nürnberg, , Germany
Ulm, , Germany
Wuerzburg, , Germany
Patras, Achaḯa, Greece
Athens, Attikí, Greece
Thessaloniki, Thessaloníki, Greece
Hksar, , Hong Kong
Pécs, Baranya, Hungary
Nyiregyhaza, Szabolcs Szatmár Bereg, Hungary
Budapest, , Hungary
Budapest, , Hungary
Debrecen, , Hungary
Meldola, Emilia Romagna, Italy
Milano, Lombardia, Italy
Catanzaro, , Italy
Pisa, , Italy
Udine, , Italy
Bergen, Hordaland, Norway
Oslo, , Norway
Badalona, Barcelona [Barcelona], Spain
Barcelona, Barcelona [Barcelona], Spain
L'hospitalet Del Llobregat, Barcelona [Barcelona], Spain
Majadahonda, Madrid, Comunidad De, Spain
San Cristobal De La Laguna, Santa Cruz De Tenerife, Spain
Valencia, Valenciana, Comunitat, Spain
Granada, , Spain
Madrid, , Spain
Madrid, , Spain
Málaga, , Spain
Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan
Taichung, , Taiwan
Tainan, , Taiwan
Plymouth, Devon, United Kingdom
Cringleford, England, United Kingdom
Birmingham, , United Kingdom
Leeds, , United Kingdom
Sheffield, , United Kingdom
Taunton, , United Kingdom
Gosford, New South Wales, Australia
Wuhan, Hubei, China
Wuhan, Hubei, China
Nanchang, Jiangxi, China
Athens, Attikí, Greece
Linz, , Austria
Glasgow, , United Kingdom
Kolkata, , India
East Melbourne, Victoria, Australia
Bologna, , Italy
Hobart, Tasmania, Australia
Rio De Janeiro, , Brazil
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Chandigarh, , India
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Tianjing, Tianjin, China
Heidelberg, , Germany
Leipzig, , Germany
Granada, , Spain
Beijing City, Beijing, China
Jinan, Shandong, China
Baton Rouge, Louisiana, United States
Meldola, Emilia Romagna, Italy
Bendigo, Victoria, Australia
Breda, Noord Brabant, Netherlands
Higashiibaraki, Ibaraki, Japan
Vienna, Wien, Austria
Nagoya, Aichi, Japan
Kashiwa, Chiba, Japan
Kitakyushu Shi, Fukuoka, Japan
Koto, Tokyo, Japan
Chiba, , Japan
Kumamoto, , Japan
Kyoto, , Japan
Okayama, , Japan
Tokyo, , Japan
Port Macquarie, New South Wales, Australia
Mohali, Punjab, India
London, Ontario, Canada
Fuzhou, Fujian, China
Chiayi City, Chiayi, Taiwan
Seoul, , Korea, Republic Of
Port Macquarie, New South Wales, Australia
Holon, , Israel
Zerifin, , Israel
Jerusalem, , Israel
Stockton, California, United States
Fukuoka, , Japan
Birmingham, , United Kingdom
Plymouth, Devon, United Kingdom
Rosario, Santa Fe, Argentina
Catanzaro, , Italy
Holon, Hamerkaz, Israel
Shanghai, Shanghai, China
Thane, Maharashtra, India
Kitakyushu Shi, Fukuoka, Japan
Nagasaki, , Japan
Abb, Ciudad Autónoma De Buenos Aires, Argentina
Córdoba, , Argentina
Salvador, Bahia, Brazil
Beijing City, Beijing, China
Jinan, Shandong, China
Roskilde, Sjælland, Denmark
Hksar, , Hong Kong
Hyderabad, Telangana, India
Itabashiku, Tokyo, Japan
Brasov, Brașov, Romania
Bucuresti, București, Romania
Timișoara, Timiș, Romania
București, , Romania
Cringleford, England, United Kingdom
Chiayi City, Chiayi, Taiwan
Wenzhou, Zhejiang, China
Sapporo, Hokkaido, Japan
Shiwa Gun Yahaba Cho, Iwate, Japan
Fukuoka, , Japan
Tokyo, , Japan
Itabashiku, Tokyo, Japan
Newark, Delaware, United States
Annapolis, Maryland, United States
Guangzhou, Guangdong, China
Udine, , Italy
Higashiibaraki, Ibaraki, Japan
Kamakura, Kanagawa, Japan
Koshigaya, Saitama, Japan
Chuo, Yamanashi, Japan
Osaka, , Japan
București, , Romania
Nyiregyhaza, Szabolcs Szatmár Bereg, Hungary
Piedecuesta, Santander, Colombia
Sofia, Sofia (Stolitsa), Bulgaria
Plovdiv, , Bulgaria
Sofia, , Bulgaria
Medellin, Antioquia, Colombia
Hyderabad, Andhra Pradesh, India
Hyderabad, Telangana, India
Higashiibaraki, Ibaraki, Japan
Kanazawa, Ishikawa, Japan
Koshigaya, Saitama, Japan
Nagasaki, , Japan
Sibiu, , Romania
Ciudad Autónoma De Buenos Aires, Buenos Aires, Argentina
Porto Alegre, Rio Grande Do Sul, Brazil
Guangzhou, Guangdong, China
Shanghai, Shanghai, China
Málaga, , Spain
Hefei, Anhui, China
Wuhan, Hubei, China
Wenzhou, Zhejiang, China
Mohali, Punjab, India
San Juan, , Puerto Rico
Taiyuan, , China
San Miguel De Tucumán, Tucumán, Argentina
Cali, Valle Del Cauca, Colombia
Vienna, Wien, Austria
Cleveland, Ohio, United States
Piedecuesta, Santander, Colombia
Buenos Aires, , Argentina
Providence, Rhode Island, United States
Shanghai, Shanghai, China
Nashville, Tennessee, United States
Houston, Texas, United States
Cali, , Colombia
Chuo, Yamanashi, Japan
San Juan, , Puerto Rico
Brasov, , Romania
București, , Romania
București, , Romania
București, , Romania
Bucuresti, București, Romania
Munich, Bayern, Germany
Hannover, Niedersachsen, Germany
Jena, Thüringen, Germany
Dresden, , Germany
Sibiu, , Romania
Dortmund, Nordrhein Westfalen, Germany
Düsseldorf, , Germany
Hyderabad, Telangana, India
Marshfield, Wisconsin, United States
Hyderabad, Telangana, India
Glasgow, Glasgow City, United Kingdom
Houston, Texas, United States
Ulm, Baden Wurttemberg, Germany
Fort Worth, Texas, United States
Greer, South Carolina, United States
Bogota, Cundinamarca, Colombia
Sofia, , Bulgaria
Brasov, , Romania
Sofia, , Bulgaria
Santa Rosa, California, United States
Stockton, California, United States
Fort Myers, Florida, United States
Saint Petersburg, Florida, United States
West Palm Beach, Florida, United States
Roanoke, Virginia, United States
Norfolk, Virginia, United States
Badalona, Barcelona [Barcelona], Spain
Minneapolis, Minnesota, United States
Vancouver, Washington, United States
Fuzhou, Fujian, China
Munich, Bayern, Germany
Hannover, Niedersachsen, Germany
Atlanta, Georgia, United States
Dortmund, Nordrhein Westfalen, Germany
Chattanooga, Tennessee, United States
Temple, Texas, United States
Nürnberg, Bayern, Germany
Santa Rosa, California, United States
Greer, South Carolina, United States
San Miguel De Tucumán, , Argentina
Thessaloniki, , Greece
Badalona, , Spain
L'hospitalet Del Llobregat, , Spain
Abb, , Argentina
Sao Paulo, , Brazil
Nyiregyhaza, , Hungary
Timișoara, , Romania
Majadahonda, , Spain
Mobile, Alabama, United States
Cerritos, California, United States
Irvine, California, United States
Los Angeles, California, United States
Atlanta, Georgia, United States
Boston, Massachusetts, United States
Little Silver, New Jersey, United States
Bronx, New York, United States
Columbus, Ohio, United States
Houston, Texas, United States
Tacoma, Washington, United States
Morgantown, West Virginia, United States
Abb, , Argentina
San Miguel De Tucumán, , Argentina
Sao Paulo, , Brazil
Wuhan, Hubei, China
Shanghai, Shanghai, China
Cali, , Colombia
Roskilde, , Denmark
Vejle, , Denmark
Patras, , Greece
Athens, , Greece
Thessaloniki, , Greece
Hyderabad, Telangana, India
Zerifin, Hamerkaz, Israel
Koto Ku, Tokyo, Japan
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Badalona, , Spain
Barcelona, , Spain
L'hospitalet Del Llobregat, , Spain
Madrid, , Spain
Valencia, , Spain
Glasgow, Glasgow City, United Kingdom
Patients applied
Trial Officials
Bristol-Myers Squibb
Study Director
Bristol-Myers Squibb
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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