Neoantigens Phase I Trial in Newly Diagnosed Glioblastoma Patients

Launched by SHANGHAI 10TH PEOPLE'S HOSPITAL · Sep 25, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a personalized cancer vaccine called the NeoPep Vaccine for patients who have recently been diagnosed with a type of brain cancer called glioblastoma. The goal is to see how safe and well-tolerated this vaccine is for these patients. To be eligible for this trial, participants should be between the ages of 18 and 70, have undergone surgery to remove most of the tumor, and be willing to receive standard treatments like chemotherapy and radiation. It’s important that they also have enough tumor tissue and blood samples for testing.

If you or a loved one qualifies for this trial, you can expect to receive close monitoring throughout the study to ensure safety. Participants will be required to sign a consent form and will need to follow specific guidelines, such as using effective contraception if they are of reproductive age. This trial is currently recruiting participants, and it offers a potential new approach to treating glioblastoma by using the body’s own immune system to fight the cancer.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Ability of subject to understand and the willingness to sign written informed consent for study participation;
• • 2. Patients with newly diagnosed high-grade glioma confirmed by histopathological and imaging evaluation;
• • 3. Gross total resection (as defined by less than 1 cm2 residual tumor mass on the largest perpendicular axes in post-operative scan taken within 48 h post-surgery; standard MRI conformable to the present national and international guidelines is sufficient)；
• • 4. At least 0.5 g tumor tissue freshly cryopreserved during surgery，and could provide adequate amounts of PBMC；
• • 5. Patient is a candidate for and willing to receive standard CRT with TMZ followed by maintenance TMZ cycles;
• • 6. Age 18-70;
• • 7. Life expectancy \> 9 months;
• • 8. KPS≥70;
• • 9. Sufficient tumor tissue samples and peripheral blood samples can be obtained for sequencing analysis, or whole exome sequencing and RNA sequencing of tumor tissue samples and peripheral blood samples have been obtained, and the sequencing data meet the prediction requirements;
• • 10. Consent of women and men of reproductive age to use adequate and effective contraception during clinical trials;
• 11. Normal laboratory values for hematology, liver and renal function (serum creatinine).In detail the following values apply as inclusion criteria:
• • 1. White blood cell count (WBC) ≥3.0×109/L；
• • 2. Absolutely neutrophil count≥1.0×109/L；
• • 3. Platelet count≥80×109/L；
• • 4. Hemoglobin content≥90g/L；
• • 5. Serum creatinine≤1.5 ULN or Creatinine clearance rate≥40 mL/min;
• • 6. TBil(total bilirubin)≤1.5 x ULN;
• • 7. Aspartic transaminase(AST)≤2.5x ULN or Alanine aminotransferase（ALT）≤2.5x ULN；Patients with liver metastases must have ≤5x ULN;
• • 8. Blood coagulation function :INR≤1.5x ULN；pT and APTT≤1.5x ULN;
• • 9. Urine protein\< 2 +;if Urine protein≥2+,24-hour urinary protein must be less than 1g.
• Exclusion Criteria:
• • 1. Patients treated with immunosuppressive agents (e.g., cyclosporin CsA, tacrolimus, rapamycin, azathioprine, etc.) within the previous month; Other immunotherapy within 3 months;
• • 2. History of other malignancies (except for adequately treated basal or squamous cell carcinoma or carcinoma in situ) within the last 5 years unless the patient has been disease-free for 5 years;
• • 3. Participated in other clinical trials within 30 days prior to screening;
• • 4. Have a history of severe allergy or allergic constitution;
• • 5. Patients who have undergone splenectomy;
• • 6. Persons with primary or secondary immunodeficiency diseases (e.g. AIDS);Patients with autoimmune diseases;
• • 7. Patients who received multiple oral, intramuscular, or intravenous corticosteroids within 30 days before the first dose; However, patients who received a single oral, intramuscular, or intravenous dose of dexamethasone of 5mg or less (or another hormone of equivalent potency) 14 days before the first dose were allowed; Allow inhaled corticosteroids to treat respiratory insufficiency (e.g., chronic obstructive pulmonary disease), or topical steroids;
• • 8. Patients with uncontrollable seizures, central nervous system disorders, or psychotic loss of cognition;
• • 9. Uncontrolled central nervous system metastases;
• • 10. Patients had a history of chronic alcohol or drug abuse in the 6 months before screening;
• • 11. With unstable systemic disease, such as active infection, liver cirrhosis, chronic renal failure, severe chronic pulmonary disease, unstable hypertension, unstable angina pectoris, congestive heart failure, myocardial infarction within one year, etc. ;
• • 12. According to this procedure, the number of candidate neoantigens that can be used to make personalized vaccines is less than 20;
• • 13. The investigator did not consider it appropriate to participate in this study.