Taiwan Real-world LDCT Screening Behavior and Outcome Research for High Risk Subjects Based on Health Promotion Administration

Launched by GEE-CHEN CHANG · Sep 23, 2022

Keywords

ClinConnect Summary

This clinical trial, called the Taiwan Real-world LDCT Screening Behavior and Outcome Research, is focused on understanding how to better screen for lung cancer in people at high risk. Lung cancer is a major health issue, especially in Taiwan, and many cases occur in people who have never smoked. The study is looking at three specific groups: individuals who were heavy smokers in the past but have quit, first-degree relatives of lung cancer patients, and people who work in high-risk environments, such as those exposed to air pollution or those with specific cooking habits.

To participate, eligible individuals must be between 50 and 80 years old and meet certain criteria, like having a family history of lung cancer or a significant history of smoking. Participants will undergo low-dose CT scans, which are special X-rays that help detect lung cancer early. The trial aims to find out how many people in these high-risk groups agree to participate in screening and how effective the screenings are at detecting lung cancer. This research will help develop better screening strategies for those most at risk.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Group 1: Previous heavy smokers Age 50 to 80 years, meet both criteria in the followings.
• • 1. Cigarette smoking of at least 20 pack-years
• • 2. With successful smoking cessation history (stopping smoking for more than 6 months), but less than 15 years
• • Group 2: First-degree relatives of lung cancer patients
• • 1. aged more than 50 years
• • 2. age less than 50 years old, but older than the age at diagnosis of the youngest lung cancer proband in the family
• • Group 3: With other high-risk occupational or environmental factors Age 50 to 80 years, meet one or more of the following criteria.
• • 1. air-pollution exposed occupations (such as traffic policemen, and street cleaners....) for at least 10 years
• • 2. cooking index ≥ 110, defined as 2/7 \* days cooking by pan frying, stir-frying, or deep frying in one week \* years cooking.
• • 3. cooking without using ventilation for more than 20 years
• • 4. history of pulmonary tuberculosis and complete anti-tuberculosis treatment with intervals more than 5 years before this study
• Exclusion Criteria:
• • 1. previous history of lung cancer
• • 2. another malignancy except for cervical carcinoma in situ or non-melanomatous carcinoma of the skin within 5 years
• • 3. an inability to tolerate transthoracic procedures or thoracotomy
• • 4. chest CT examination was performed within 18 months
• • 5. hemoptysis of unknown etiology within one month
• • 6. body weight loss of more than 6 kg within one year without an evident cause
• • 7. a known pregnancy
• • 8. Not capable of understanding or responding to the written questionnaire even through the help from the study team