Tranexamic Acid to Prevent Heavy Bleeding After Childbirth in Women At Higher Risk

Launched by LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE · Sep 27, 2022

Keywords

ClinConnect Summary

The I'M WOMAN trial is a research study looking at whether a medication called tranexamic acid (TXA) can help prevent heavy bleeding after childbirth, known as postpartum hemorrhage (PPH). This condition can be very serious and affects many women every year. The trial will test how well TXA works when given just before delivery, either through an injection into the muscle or directly into the bloodstream. Researchers will also look at any side effects and how the treatment affects the overall health of mothers after giving birth.

To take part in this study, women must be 18 years or older and admitted to the hospital for childbirth, either vaginally or by cesarean section, and have one or more known risk factors for heavy bleeding. However, women who have specific reasons not to use TXA will not be included. If you join the trial, you can expect to receive the medication just before you give birth and be monitored for any effects on your health and the health of your baby. This study aims to find a way to make childbirth safer for women at risk of heavy bleeding.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women aged 18 years or older who are admitted to hospital to give birth vaginally or by caesarean section, who have one or more known risk factors for PPH
• Exclusion Criteria:
• • Women who have a clear indication or contraindication for TXA