Absolute Coronary Flow in Patients With Heart Failure With Reduced Ejection Fraction and Left Bundle Branch Block With Cardiac Resynchronization Therapy

Launched by ASHKAN EFTEKHARI · Sep 29, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating how cardiac resynchronization therapy (CRT) affects blood flow in the heart, specifically in patients who have heart failure with a condition called left bundle branch block (LBBB). CRT is a treatment that helps the heart beat more efficiently, but not everyone benefits from it. The researchers want to find out if improving blood flow in the coronary arteries, particularly the left anterior descending artery (LAD), can help patients feel better after receiving CRT. They believe that better heart function after CRT is not just about how the heart pumps, but also about better blood flow to the heart muscle.

To take part in this study, participants must be adults over the age of 18, have LBBB, and have heart failure due to a condition called dilated cardiomyopathy. They should also be stable on their heart medications and have a CRT device implanted. During the study, participants will undergo tests to measure blood flow in their coronary arteries with the CRT device turned on and off. This research could provide valuable insights into how to improve treatment for heart failure patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \> 18
• • QRS ≥ 150 ms before implantation
• • Heart failure because of dilated cardiomypathy
• • Sinus rhythm
• • Stable medical therapy
• • LBBB
• • CRT device
• Exclusion Criteria:
• • eGFR \< 30 ml/min
• • Severe valvular heart disease
• • Permanent atrial fibrillation or atrial flutter
• • Prior PCI or CABG
• • Prior myocardial infarction
• • Heart failure due to ischemic heart disease
• • Other type of device (pacemaker, ICD)
• • Not able to give informed consent
• • Does not understand Danish