Combined Study of ATrial Strain and Voltage by High Density Mapping in Young Patients With Atrial Fibrillation.

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Oct 3, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at a new approach to manage atrial fibrillation (AF), which is a heart condition where the heart beats irregularly. The study aims to explore how combining different tests and measurements can help doctors better understand and treat AF, especially in younger patients. The trial will focus on patients who have had AF for at least three months and who are considering a treatment called catheter ablation, a procedure that targets the areas of the heart causing the irregular heartbeat.

To participate in this trial, you need to be between 18 and 60 years old and have a diagnosis of paroxysmal or persistent AF. Your heart should be structurally healthy, meaning it functions well and has no major issues. If you join the study, you'll go through various tests to help researchers gather important information about your condition. The trial is not yet recruiting participants, so if you think you might be eligible, keep an eye out for updates!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patient aged 18 to 60 years
• • 2. Established diagnosis of paroxysmal or persistent symptomatic atrial fibrillation (AF) for at least 3 months with indication of catheter ablation
• • 3. AF episode documented by ECG in the last 12 months
• • 4. Structurally healthy heart, with an LVEF\> 50%, an interventricular septum \<12 mm and an OG volume \<40mL / m ² by TTE
• • 5. Having given their informed consent in writing
• • 6. Affiliated with or entitled to a French social security scheme
• Exclusion Criteria:
• • 1. Mitral valve disease with grade 2 to 4 insufficiency
• • 2. Heart failure (NYHA stage II to IV in sinus rhythm and LVEF \< 50%), hypertrophic heart disease or congenital heart disease
• • 3. Contraindication to oral anticoagulation
• • 4. Intracardiac thrombus
• • 5. History of ablation of the left atrium
• • 6. History of heart surgery
• • 7. Contraindication to performing MRI or using the DOTAREM™ contrast medium (pacemaker, defibrillator, prosthesis, old generation heart valves, old generation ferromagnetic vascular surgical clips, treatment type endocranial aneurysms, neurosimulator, cochlear implants, automated injection device such as insulin pump, and more generally any non-removable electronic medical device or equipment, kidney disease with GFR \< 30 mL/min, hypersensitivity to gadoteric acid or to excipients)
• • 8. History of myocardial infarction or coronary angioplasty within the last three months
• • 9. Chronic obstructive pulmonary disease
• • 10. Under guardianship or curatorship
• • 11. Women who are pregnant, breastfeeding or of childbearing age in the absence of effective contraception
• • 12. Participation in another interventional research involving a health product