The Effects of ECMO on the Pharmacokinetics of Hydromorphone

Launched by XIAOBO YANG, MD · Sep 29, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how the body processes a pain medication called hydromorphone in patients who are on a special life-support system known as ECMO (Extracorporeal Membrane Oxygenation). The goal is to understand how to best dose this medication in patients receiving ECMO treatment to ensure they get the right amount for effective pain relief.

To participate in the study, individuals must be between 18 and 80 years old, currently using hydromorphone for pain relief, and have been on ECMO for more than four days. Unfortunately, those who are allergic to hydromorphone, pregnant, or have certain liver problems won't be able to join. Participants in this study can expect to have their medication levels monitored closely, which will help doctors find the best approach for managing pain in patients receiving ECMO. The trial is currently recruiting, so there are opportunities for eligible patients to take part.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Between the ages of 18 and 80;
• • Using hydromorphone for pain relief;
• • Using ECMO for more than 96h
• Exclusion Criteria:
• • Allergic to hydromorphone;
• • Use of CRRT during ECMO;
• • Liver function Child-Pugh B, C grade;
• • Pregnancy;
• • Intestinal obstruction;
• • Refused to sign the informed consent.