Multicentric Study on Clopidogrel Resistance in DAPT for CAS (MULTI-RESCLOSA)

Launched by IRCCS POLICLINICO S. DONATO · Sep 30, 2022

Keywords

ClinConnect Summary

This clinical trial, called MULTI-RESCLOSA, is studying how different medications affect patients undergoing a procedure called carotid stenting, which is used to treat narrowed arteries in the neck. Specifically, the trial is comparing the effects of two blood-thinning medications: Clopidogrel and Ticagrelor. Researchers want to find out if patients who do not respond well to Clopidogrel (known as "non-responders") have better outcomes when treated with Ticagrelor, particularly in terms of serious health issues like heart attacks or strokes, as well as bleeding problems, in the months following the procedure.

To participate in this study, patients must be adults over 18 years old and willing to give their consent. They should be receiving treatment for carotid stenosis (the narrowing of the arteries) using the stenting technique at specific hospitals involved in the trial. However, minors, those who do not consent, patients with certain types of carotid stenosis that cannot be treated with stenting, and pregnant or breastfeeding women cannot participate. Participants will be monitored for their health outcomes after the procedure, helping researchers learn more about the best treatment options for patients with carotid stenosis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • adult patients (age\> 18 years)
• • patients who have given their consent to participate in the study, belonging to the U.O. of Vascular Surgery of the IRCCS Policlinico San Donato and the U.O. of Vascular Surgery of the participating centers and subjected to the treatment of carotid stenosis by stenting technique.
• Exclusion Criteria:
• • underage patients
• • patients who have not given their consent to participate in the study,
• • patients who have carotid stenosis not susceptible to intervention by stenting
• • pregnant or lactating women (such as situations in which carotid stenting is contraindicated regardless of the execution of the study).