Evaluation of 18F-TFB PET/CT Scan in Patients With Differentiated Thyroid Cancer

Launched by MAYO CLINIC · Oct 7, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at a special type of scan called the 18F-TFB PET/CT scan to see how well it can detect thyroid cancer that has come back or spread to other parts of the body. The study focuses on patients with differentiated thyroid cancer, which includes papillary and follicular types. By using this new imaging method, the researchers hope to find out if it can provide better information for doctors compared to the standard imaging tests currently used.

To be eligible for this trial, participants must be at least 18 years old and have a confirmed diagnosis of papillary or follicular thyroid cancer. They should also be scheduled for a specific type of scan called a total body iodine scan. Participants will need to lie still for about 65 minutes during the PET/CT scan. The study is currently recruiting patients, and it's important that those interested do not have certain recent medical procedures or medications that could affect the results. Overall, the trial aims to improve how doctors monitor and treat patients with thyroid cancer.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subject has biopsy-proven papillary or follicular thyroid cancer
• • Subject is clinically indicated for 123I-SPECT/CT total body iodine (TBI) scan
• • Subject agrees to undergo 18F-TFB PET/CT scan following TBI scan
• • Karnofsky performance status of \>= 50 (or Eastern Cooperative Oncology Group \[ECOG\]/World Health Organization \[WHO\] equivalent)
• • Subject is able to be scanned - able to lie still on SPECT/CT and PET/CT scanner table for up to 65 minutes (min)
• • Age 18 or older
• • Ability to understand a written informed consent document, and the willingness to sign it
• • Subject is not pregnant
• Exclusion Criteria:
• • Contrast-enhanced CT within 4 last weeks
• • Amiodarone within last 4 months
• • Ingested iodine, kelp tablets, Lugols iodine, or potassium iodide (SSKI) within 2 weeks
• • Unable to lie flat, still or tolerate a PET scan
• • Applied betadine, iodoform, or quick tanning products to skin within last two weeks
• • If using medication withdrawal for stimulation, then exclude if thyroid stimulating hormone (TSH) level \< 25
• • Taken anti-thyroid medication within 1 week
• • Subject is breastfeeding
• • Positive pregnancy test