Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients

Launched by JONA HATTANGADI-GLUTH · Oct 7, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how radiation therapy affects the thinking and memory skills of patients with primary brain tumors, such as gliomas, meningiomas, and schwannomas. Researchers want to understand the relationship between the amount of radiation given and any cognitive changes that may occur. By using special brain imaging and cognitive tests, the study aims to find ways to protect brain function while treating these tumors.

To participate in this study, you need to be at least 18 years old, have a certain level of health (Karnofsky performance status of 70 or higher), and be expected to live for at least a year. You should be planning to receive a specific type of radiation treatment called fractionated partial brain radiation. Participants will undergo neurocognitive assessments and brain scans throughout the study. It’s important to note that if you have had previous radiation therapy to the brain or cannot have an MRI, you may not be eligible. This research is important because it could lead to better treatment strategies that minimize side effects on thinking skills.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients 18 years or older
• • 2. Karnofsky performance status (KPS) ≥70
• • 3. Life expectancy of ≥1 year
• • 4. Primary brain tumor patients who will receive fractionated partial brain RT
• • 5. Able to complete neurocognitive assessments
• Exclusion Criteria:
• • 1. Inability to undergo MRI with contrast
• • 2. Prior brain RT