CO2 Gap Changes in Septic Shock in Relation to Cardiac Output

Launched by CAIRO UNIVERSITY · Oct 10, 2022

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Introduction

Shock is defined as a life-threatening, generalized acute circulatory failure with inadequate cellular oxygen utilization \[1\]. One of the goals of acute circulatory failure treatment is to increase cardiac output \[2\].

The ∆PCO2 is defined by the difference in the partial pressure of carbon dioxide (PCO2) between mixed or central venous blood and arterial blood \[1\]. The ∆PCO2 has been correlated to outcome and mortality \[3\].

The mixed ∆PCO2 difference has been shown to be inversely correlated with the cardiac index (CI). A central venous PCO2, which is easier to obtai...

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Eligibility criteria

• Inclusion Criteria:
• • adult patients admitted to critical care department of Cairo university hospitals with septic shock and elevated blood lactate level \> 2 mmol/ L requiring fluid resuscitation and/ or vasopressor drugs infusion.
• Exclusion Criteria:
• • Patients with advanced cardiac, pulmonary, hepatic, or renal diseases were excluded from enrolment.