TB Case-Finding, Treatment and Prevention Intervention in Thailand

Launched by INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT · Oct 11, 2022

Keywords

ClinConnect Summary

This clinical trial is exploring a new way to find and prevent tuberculosis (TB) in people who live with someone diagnosed with the disease. The goal is to catch TB early in these household contacts to help reduce sickness, death, and the spread of TB in Thailand. Over the next three years, researchers will compare this new approach to the current methods used to manage TB, working closely with health organizations in Thailand and the UK.

To participate in this study, you need to be at least 18 years old and have been recently diagnosed with TB. You must also live with someone who has TB and have reported at least one contact who shares your living space. All household members, including children, can take part, as long as they have given consent or have permission from a parent or guardian. Participants can expect to undergo regular health checks and receive support throughout the study. It's important to note that individuals with certain types of drug-resistant TB or those currently undergoing TB treatment cannot join the trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Inclusion of the index cases
• • Age ≥18 years
• • Newly bacteriologically confirmed TB case (within 1 month of diagnosis)
• • Living in the same household for the last 3 months
• • Reporting at least one HH contact
• • Providing written informed consent for participation in the study
• • Inclusion of contacts
• • All contacts living in the same HH, defined as any person who shared the same enclosed living space as the index TB case for one or more nights or for frequent or extended daytime periods for at least one month before the TB diagnosis is made.
• • Providing written informed consent (signed by adult (≥18 years) contacts; or by parents/guardians for minors \< 13 years or incapacitated people; written assent for children ≥13 years and \< 18 years).
• Exclusion Criteria:
• • Exclusion of index cases
• • Index case who do not live in the catchment area of the study cluster
• • Index cases diagnosed with rifampicin resistance, multidrug resistance (MDR) or extensively drug-resistant (XDR-TB)
• • Index cases who are incarcerated
• • Exclusion of the contacts
• • - contact currently on TPT or on TB treatment or who finished such treatment in the last 3 months.