Prevalence and Etiologies of Intracranial Stenosis in Patients With Antiphospholipid Syndrome

Launched by CHINESE UNIVERSITY OF HONG KONG · Oct 13, 2022

Keywords

ClinConnect Summary

In the proposed cross-sectional study, we aim to determine the prevalence of intracranial stenosis, and to explore the correlations between the neuroimaging findings and the immunological as well as clinical features in patients with APS.

Upon reviewing the clinical and laboratory information in the medical specialist out-patient clinics, electronic patient record and/or through the Clinical Data Analysis And Reporting System (CDARS), investigators shall identify and recruit on-site APS patients who fulfilled the modified Sapporo criteria, currently aged ≥18 years, and receive care from th...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• 1. Patients diagnosed with APS who fulfilled the modified Sapporo criteria:
• • 1. at least one clinical criterion (vascular thrombosis or pregnancy morbidity); and
• 2. laboratory criteria (aPL positivity twice, 12 weeks apart):
• • i. Lupus anticoagulant positivity requires screening, mixing, and confirmation test as per International Society of Thrombosis and Hemostasis guidelines (11). ii. Anticardiolipin antibodies positivity requires a medium to high titer IgG and/or IgM level by ELISA assays. iii. Anti-β2 glycoprotein antibodies positivity requires a \>99th titer IgG and/or IgM level by ELISA assays.
• • 2. Patients age ≥18 years
• • 3. Patients who are able to provide an informed consent to study procedures
• Exclusion Criteria:
• • 1. Patient with established neurological disease, such as stroke, cerebral venous thrombosis, vasculitis of the central nervous system, cerebral lupus, etc.
• • 2. Patient contraindicated to contrast MRI scans. E.g. claustrophobia, allergy to gadolinium contrast, MRI incompatible implants, estimated glomerular filtration rate of \< 30mL/min/1.73m2.