Ventilator-induced Right Ventricular Injury During EIT-based PEEP Titration in Patients With ARDS

Launched by UNIVERSITY OF PADOVA · Oct 13, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating how different levels of a treatment called positive end-expiratory pressure (PEEP) can affect the heart, specifically the right ventricle, in adult patients with moderate to severe acute respiratory distress syndrome (ARDS). ARDS is a serious condition that makes it hard to breathe, and using a ventilator can sometimes worsen heart problems. The researchers aim to find the best PEEP levels to help protect the heart while still providing effective breathing support. They will use a non-invasive technique called electrical impedance tomography (EIT) to monitor lung health and determine the most suitable PEEP levels for patients.

To participate in this study, patients must be diagnosed with moderate to severe ARDS within the last 72 hours and require a ventilator. Eligible participants will be adults aged 18 and older. During the trial, patients will undergo tests to evaluate their heart function while receiving mechanical ventilation at different PEEP levels. This research could lead to better care for patients with ARDS, helping to reduce heart-related complications during treatment.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • 1. Moderate to severe acute respiratory distress syndrome
• • 2. Inclusion within 72 hours of acute respiratory distress syndrome diagnosis
• • 3. Endotracheal intubation or tracheostomy
• Exclusion criteria:
• • 1. Age lower than 18 years old
• • 2. Pregnancy
• • 3. Absence of informed consent
• • 4. Thoracic surgery or lung transplant during the admission
• • 5. Contraindications to recruitment maneuvers (mean arterial pressure lower than 65 mmHg despite administration of fluids or vasopressors, active air leaks through a chest tube, pneumothorax or subcutaneous or mediastinal emphysema in absence of chest drainage)
• • 6. Contraindications to electrical impedance tomography (contraindication to recruitment maneuvers, presence of pacemakers or other electronic devices in the chest, injuries or burns in the electrode placement area)