Stand Up for Your Health with a Sit-stand Desk

Launched by MEDICAL COLLEGE OF WISCONSIN · Oct 15, 2022

Keywords

ClinConnect Summary

This clinical trial, titled "Stand up for Your Health With a Sit-stand Desk," is exploring whether using a sit-stand desk at work can help improve health for people who are at risk of developing type 2 diabetes. Specifically, the study will involve 198 overweight or obese adults who have sedentary jobs, meaning they spend most of their workday sitting. Participants will be divided into three groups: one group will use a sit-stand desk aiming for 2 hours of standing each day, another group for 3 hours, and the last group will serve as a control without any desk intervention. The researchers want to see if standing more during work hours can help improve their insulin sensitivity and overall metabolic health.

To be eligible for this trial, individuals need to be employees of the Medical College of Wisconsin, have a body mass index (BMI) over 25, and meet certain risk factors for diabetes, such as having prediabetes or other health issues. Participants can expect to wear a small device on their thigh that will track their activity levels and sitting time over the course of the study. This trial is important because it builds on earlier findings that suggest reducing sitting time can lead to better health outcomes, even without changes in exercise or weight. If you're interested and meet the criteria, this could be a great opportunity to contribute to research that may benefit many people at risk for diabetes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Overweight or obese (body mass index of 25 kg/m2 or higher)
• • 2. Employees with "sedentary" jobs, defined as spending at least 75% of their (8 hours or more) workday sitting at a desk (at home or in an office)
• 3. Defined as "at-risk" for diabetes, defined as either:
• • 1. Prediabetes (HbA1c of 5.7% to 6.4%) or a fasting glucose of 100 to 125 mg/dL
• • 2. Having one or more additional risk factors: (beyond BMI\>25)
• • Age 45 years or older
• • Family history of diabetes mellitus in a first-degree relative
• • Physical inactivity (no structured exercise activity)
• • History of gestational diabetes, hypertension, or dyslipidemia
• • African American, Alaska Native, American Indian, Asian American, Hispanic/Latino, Native Hawaiian, or Pacific Islander ethnicity
• Exclusion Criteria:
• • 1. Established cardiovascular disease (myocardial infarction, coronary stent, coronary artery bypass grafting, cardiac transplant, or angina)
• • 2. Established congestive heart failure or cardiomyopathy
• • 3. Established peripheral vascular disease
• • 4. Established diabetes (HbA1c ≥ 6.5% or on diabetes medications or insulin)
• • 5. Chronic musculoskeletal disorders involving the lower extremities, such as arthritis of the knees or hips, or regular use of ambulatory assist devices such as a walker or cane
• • 6. Neuropathy of any etiology
• • 7. Positional syncope or history of orthostasis
• • 8. Less than 4 days/week at any single office (or work-from-home) location.
• • 9. Current use of a standing desk for work
• • 10. Tobacco use within the previous 12 months
• • 11. Current illicit drug use or excessive alcohol use (defined as more than 14 drinks/week for women, more than 28 drinks/week for men)
• • 12. Steroid use ≥21 days/year
• • 13. Fasting triglyceride level ≥ 500 mg/dL
• • 14. Thyroid disease
• • 15. Uncontrolled or untreated hypertension(\>150/90 mm Hg)
• • 16. Pregnant or lactating (or plans to become pregnant in the next 6 months)
• • 17. LDL cholesterol ≥ 190mg/dL
• • 18. Currently enrolled or plans to diet or join a weight loss program over the next 6 months.
• • 19. Non-English speaker