Comparison of Efficacy of Metoclopramide , Promethazine and Prochloroperazine in the Treatment of Vertigo.

Launched by OMAN MEDICAL SPECIALITY BOARD · Oct 18, 2022

Keywords

ClinConnect Summary

This clinical trial is looking to compare the effectiveness of three different medications—metoclopramide, promethazine, and prochloroperazine—in treating acute peripheral vertigo, which is a type of dizziness often accompanied by nausea or vomiting. The study is taking place in emergency departments across three hospitals in Oman and aims to find out which of these medications works best for patients experiencing these symptoms.

To participate in this trial, individuals must be between the ages of 18 and 60 and have experienced acute peripheral vertigo with a significant level of nausea or vomiting, starting within the last three days. However, people over 60 years old, those with certain medical conditions like epilepsy or dementia, and pregnant women are not eligible. Participants will receive one of the three medications and will be monitored to see how well it helps with their symptoms. This study is currently recruiting participants and will continue until August 2024.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • □ Acute peripheral vertigo with nausea or vomiting (vas, visual analog scale \>5) during their emergency department episode of care for which the attending physician recommending antiemetic, onset with in 3 days .
• • Age( 18- 60).
• Exclusion Criteria:
• • • Age \>60.
• • Any organic brain disease (Clear central cause; "malignancy with brain metastasis".)
• • History of epilepsy
• • Pregnancy.
• • Dementia, Parkinson's disease
• • Abnormal vital signs
• • Any known drug allergy to the study drugs
• • Undergoing chemotherapy or radiotherapy
• • Mechanical bowel obstruction or perforation, gastrointestinal bleeding
• • Inability to understand study explanation or outcome measures (any reason)
• • Patients who refused to participate study.