Sleep Disordered Breathing With Opioid Use

Launched by VA OFFICE OF RESEARCH AND DEVELOPMENT · Oct 18, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating how certain treatments can help improve breathing problems during sleep for veterans who use prescription opioids. Opioids, commonly used for pain management, can sometimes lead to serious sleep issues, including a condition called central sleep apnea, where breathing becomes irregular during sleep. The researchers want to see if using oxygen and a medication called acetazolamide can help stabilize breathing and reduce sleep apnea symptoms in these individuals. They will also look at how these issues affect the overall quality of life, sleep, and pain levels in veterans.

To participate in this study, veterans aged 18 to 89 who are currently taking prescription opioids can apply. However, some individuals will not be eligible, including those with severe obesity, certain heart conditions, or significant untreated mental health issues. If you join the trial, you can expect to undergo various assessments to help understand how your sleep and health are affected by opioid use and the treatments being tested. Ultimately, this trial aims to find new ways to improve sleep and health for veterans experiencing these challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Veterans, age 18-89 years
• • Veterans with prescription opioids
• Exclusion Criteria:
• • Patients with BMI\>40kg/m2 will be excluded to avoid the effects of morbid obesity on pulmonary mechanics and ventilatory control
• • Patients with history of unresolved/untreated cardiac disease, including recent myocardial infarction, recent bypass surgery, untreated atrial and ventricular tachy-bradycardias
• • Congestive heart failure with Cheyne-Stokes respiration (CSR)
• • Current unstable angina
• • Recent stroke
• • Untreated schizophrenia
• • Untreated hypothyroidism
• • Unresolved seizure disorder
• • Severe respiratory, neurological, liver and renal diseases
• • Unstable psychiatric disorders/untreated PTSD
• • Traumatic brain injury
• • Pregnant women
• • Significant sleep disorder such as narcolepsy, parasomnias disorder
• • Failure to give informed consent
• • Patients on tramadol and suboxone/buprenorphine