A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies

Launched by OSSIUM HEALTH, INC. · Oct 18, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a new approach to help patients with acute leukemias, such as acute lymphoblastic leukemia and acute myeloid leukemia, by using bone marrow from deceased donors for transplantation. The main goal is to see if this method is safe and feasible for patients who need a transplant. Participants will undergo a conditioning treatment before the transplant and will be monitored closely for 56 days after the procedure to ensure their safety. They will also continue to be followed for a year to track their progress.

To be eligible for this trial, participants should be between 18 and 55 years old if they are receiving more intensive treatment, or up to 70 years old for a gentler approach. They need to have a specific type of acute leukemia and meet certain health criteria, including good organ function. It's important that potential participants are willing to follow the study procedures and can provide informed consent. This trial is currently recruiting patients, so if you or someone you know might be interested, it's a good idea to discuss it with a healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient has the ability to provide informed consent according to the applicable regulatory and local institutional requirements
• • Male or female, aged ≥18 and ≤65 years for patients receiving MAC (Regimen A or Regimen B); aged ≥18 and ≤75 years for patients receiving RIC (Regimen C or D)
• • Patient must require allogeneic HCT per the discretion of the treating physician
• • Patient must be high-resolution, HLA partially or fully matched (4-8/8 allele matched at HLA-A, -B, -C, DRB1) to an available Ossium HPC, Marrow product
• • Stated willingness to comply with all study procedures and availability for the duration of the study
• * Diagnosed with malignant hematologic disease including:
• • 1. Acute leukemia \[acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), acute biophenotypic leukemia (ABL), or acute undifferentiated leukemia (AUL)\], MDS without fibrosis, or chronic leukemia (CLL, CML) in the first remission or beyond with ≤5% marrow blasts documented by bone marrow assessment and no circulating blasts or extra-medullary disease within 42 days prior to anticipated start of conditioning
• • 2. Chemosensitive non-Hodgkin's lymphomas, Hodgkin's lymphoma, or cutaneous T cell lymphomas in the first remission or beyond documented by PET/CT imaging and bone marrow assessment within 42 days prior to anticipated start of conditioning
• • Karnofsky performance status score ≥70% (MAC) or ≥60% (RIC)
• • HCT comorbidity index (HCT-CI) ≤5
• * Adequate organ function defined as:
• • 1. Cardiac: LVEF at rest ≥40% (RIC) or LVEF at rest ≥45% (MAC)
• • 2. Pulmonary: DLCO, FEV1, FVC ≥50% predicted by pulmonary function tests (PFTs). DLCO value may be corrected for hemoglobin.
• • 3. Hepatic: total bilirubin ≤2.0 mg/dL, and ALT, AST, and ALP \<3 x upper limit normal (ULN), unless ALT, AST, and/or ALP are disease related
• • 4. Renal: SCr within 1.5x normal range for age. If SCr is outside normal range for age, CrCl\> 60 mL/min/1.73m2 must be obtained (measured by 24-hour urine specimen or nuclear glomerular filtration rate (GFR), or calculated GFR)
• Exclusion Criteria:
• • Availability of suitable graft from living donor (defined as 7/8 or 8/8 HLA-matched related or unrelated donors, haploidentical donors, or cord blood donors)
• • Prior autologous or allogeneic HCT
• • Pregnancy or lactation
• • Ongoing treatment with an investigational drug used for disease-related treatment within 5 half-lives of the drug
• • Current uncontrolled bacterial, viral or fungal infection defined as currently taking medication with evidence of progression of clinical symptoms or radiologic findings
• • Any condition(s) or diagnosis, both physical or psychological, or physical exam finding that in the investigator's opinion precludes participation