Bacterial Composition and Recurrent Cystitis in Postmenopausal Women After Treatment With Lactobacilli.

Launched by AALBORG UNIVERSITY HOSPITAL · Oct 19, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how a treatment with lactobacilli, which are good bacteria, affects the bacteria in the urine, vagina, and feces of postmenopausal women. The researchers want to find out if this treatment can change the bacterial composition in urine and if it helps prevent repeated bladder infections, known as cystitis. Women who have experienced recurrent cystitis will participate in the study and will be monitored for six months. They will receive either a placebo (a look-alike substance with no active ingredients) or lactobacilli tablets, with a switch after three months, so everyone gets to try both treatments.

To be eligible, participants must be postmenopausal women, aged 60 or older if they had a hysterectomy, and have a confirmed diagnosis of recurrent cystitis. Throughout the study, participants will visit the hospital every 1.5 months to provide samples and answer health-related questions. This research aims to better understand the role of good bacteria in the body and how they might help with recurrent bladder infections.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • postmenopausal women
• • if hysterectomy before menopause, then age of \>60 years
• • verified diagnose of recurrent cystitis. (two in 6 months or 3 in a year, verified by cultivation)
• • able to speak and write Danish
• Exclusion Criteria:
• • vaginal prolapse with symptoms
• • residual urine over 150 ml
• • bladder diseases
• • profylactic antibiotics
• • probiotics
• • bladder cancer
• • genital cancer.