Early Severe Illness TrAnslational BioLogy InformaticS in Humans

Launched by LONDON HEALTH SCIENCES CENTRE RESEARCH INSTITUTE OR LAWSON RESEARCH INSTITUTE OF ST. JOSEPH'S · Oct 20, 2022

Keywords

ClinConnect Summary

The clinical trial titled "Early Severe Illness TrAnslational BioLogy InformaticS in Humans" is focused on understanding critical illnesses like sepsis and acute respiratory distress syndrome (ARDS), which can occur after severe infections or trauma. These conditions often overlap and can make it hard for doctors to provide the right treatment quickly. Unfortunately, about 1 in 4 patients in intensive care units (ICUs) do not survive due to a lack of specific therapies. This study aims to identify biological signs in patients when they first arrive at the ICU to help diagnose these conditions earlier and potentially discover new treatments.

To participate in this study, individuals must be at least 18 years old, have been admitted to the ICU within 48 hours of showing signs of critical illness, and have been seen in the emergency department within the past 72 hours. Key signs of critical illness can include confusion, low blood pressure, difficulty breathing, or suspected severe infection. Participants can expect to provide biological samples and have their health tracked to help researchers learn more about these life-threatening conditions. This is an observational study, meaning participants will not receive new treatments during the trial, but their involvement could lead to better care for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years old
• • ≤48h since ICU admission
• • ICU admission within 72h of presentation to the emergency department (ER)
• * Clinical critical illness suspected on the basis of any one of the following:
• • 1. Altered mental status (GCS\<15)
• • 2. Cardiovascular collapse (presence of any: Heart rate \>90, systolic blood pressure \<90, presence of vasopressors, lactate \>2.0)
• • 3. Respiratory collapse (presence of any: respiratory rate \>20, PaCO₂ \<32 mm Hg, supplemental oxygen, invasive or non-invasive ventilation)
• • 4. Suspected severe infection (presence of any: temperature \>38°C or \<36°C, white blood cell (WBC) count \>12,000/mm³ or \<4,000/mm³, presence of 1 or more antibiotics at the time of ICU admission)
• Exclusion Criteria:
• • Age \<18 years old
• • \>48h since ICU admission
• • Admission to ICU in patients \>72h after the presentation to the ER
• • No evidence of critical illness (ICU admission due to bed-spacing)