Neuroimaging Combining Biomarkers for Identifying Long-term Cognitive Dysfunction and Delirium

Launched by RENJI HOSPITAL · Oct 23, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how to better identify patients at risk for cognitive problems and delirium after heart surgery. Researchers want to use advanced brain imaging (called MRI) to find signs of small blood vessel disease in the brain, which can lead to confusion and memory issues in older patients. They are also looking for specific biomarkers, which are biological signs that can indicate a higher risk of these problems, to help identify patients who might experience cognitive difficulties after their surgery.

To participate in this trial, you need to be between 50 and 85 years old and scheduled for elective heart surgery. You will also need to give written consent before the surgery. However, individuals with certain mental health issues, other diseases that can cause memory problems (like Alzheimer’s), or severe cancers will not be eligible. If you join the study, you can expect to undergo MRI scans and other assessments to help researchers understand more about how to prevent or manage cognitive issues after surgery. This research could ultimately lead to better care for patients undergoing heart surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age from 50 years to 85 years;
• • 2. The patient is going to have selective cardiac surgery;
• • 3. Written informed consent is obtained before the surgery.
• Exclusion Criteria:
• • 1. mental illness;
• • 2. Already have other diseases that can cause dementia, such as Alzheimer's disease, Lewy body dementia, Frontotemporal dementia, progressive supranuclear palsy, Parkinson's disease, Creutzfeldt-Jakob disease, Huntington's disease, alcohol and drug dependence, Neurosyphilis, systemic lupus erythematosus; or preoperative MRI shows hippocampal and temporal lobe atrophy more than three levels
• • 3. Have suffered from other brain diseases (such as overt stroke, multiple sclerosis, central nervous system infection with sequelae, etc.);
• • 4. Preoperative MRI indicates covert stroke MMSE or MoCA scale cannot be completed due to other reasons (such as hearing impairment or visual impairment)
• • 5. MRI contraindications before or after surgery or patients who cannot tolerate MRI imaging
• • 6. Stage 3 or 4 malignant tumors, and high malignancy and poor prognosis cancer, such as pancreatic cancer, gallbladder cancer, and bile duct cancer.