The Enteral Resuscitation In Intensive Care Pilot- Study

Launched by MEDICAL UNIVERSITY OF VIENNA · Oct 22, 2022

Keywords

ClinConnect Summary

The Enteral Resuscitation In Intensive Care Pilot Study is a research project aimed at improving how we provide fluids to critically ill patients. This study compares the usual method of giving fluids through an intravenous (IV) line to a new approach that delivers fluids directly into the stomach (enteral administration). The goal is to gather information that could lead to better treatment options for patients facing electrolyte imbalances and other related issues in intensive care units.

To participate in this study, patients need to be over 18 years old and have been intubated (a tube placed in the windpipe to help with breathing) within the last 72 hours. They should also require a specific amount of fluid that does not exceed 4 mL per kilogram of body weight per hour for at least 24 hours. However, individuals with severe gastrointestinal issues, recent abdominal surgery, or certain medical conditions may not be eligible. Participants will receive either the standard IV fluids or the new enteral fluids, and their health will be monitored closely. This study is currently recruiting participants, and it’s an important step toward improving care for critically ill patients.

Gender

ALL

Eligibility criteria

• * Inclusion criteria:
• • Patient intubated within the last 72h
• • Age \>18 years
• • Expected required fluid volume may not exceed 4 mL/kg/h (permanently, during at least 24 hours).
• • Negative pregnancy test in female patients of childbearing potential
• • Informed consent. For patients that are temporarily unable to consent a
• • subsequent informed consent must be provided.
• * Exclusion criteria:
• • Evidence of severe gastrointestinal disease defined as
• • Gastrointestinal Failure with \> 3 symptoms (see below) or
• • Lactate \>3mmol/L when mesenterial ischemia is a probable cause
• • Clinical signs of intra-abdominal hypertension and an increase of intra-abdominal pressure of \>20 mmHg.
• • Patients who cannot receive early enteral nutrition due to conditions such as prone positioning in consequence of conditions such as acute respiratory distress syndrome
• • Pregnancy
• • Abdominal surgery in the last 3 months (unless all involved physicians, study investigators and caretaking doctors agree that the surgical event does not constitute a limitation for enteral fluid administration)
• • Postoperative patients with consecutive admission to ICU
• • Extracorporeal Kidney-Replacement Therapy before intubation
• • At the discretion of the Investigator
• Symptoms of Gastrointestinal Failure:
• • Absent bowel sounds
• • Bowel distension
• • Vomiting/regurgitation volume \>500 ml
• • GI bleeding
• • Diarrhoea (liquid stool \>3 times a day)
• • Distended stomach on ultrasound examination.