A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
Launched by HOFFMANN-LA ROCHE · Oct 24, 2022
Trial Information
Current as of June 27, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a new medication called astegolimab to see how well it works and how safe it is for people with Chronic Obstructive Pulmonary Disease (COPD). This study is specifically for individuals who are former or current smokers and have experienced frequent worsening of their COPD symptoms. Participants will be compared to a group receiving a placebo, which is a treatment that looks like the real medicine but doesn't contain active ingredients. The goal is to find out if astegolimab can help reduce these flare-ups and improve overall lung function.
To be eligible for this trial, participants must have a diagnosed history of COPD for at least a year, have had at least two moderate or severe flare-ups in the past year, and meet specific lung function criteria. They should also be current smokers or have a history of smoking a certain amount. Participants will need to be stable on their current COPD treatment for at least a month before joining the study. If someone decides to participate, they can expect regular check-ups and assessments over the course of the trial to monitor their health and response to the treatment. This study is currently recruiting participants, and all genders are welcome to join.
Gender
ALL
Eligibility criteria
- • Inclusion Criteria
- • Documented COPD diagnosis for ≥ 12 months
- • History of frequent exacerbations, defined as having had 2 or more moderate or severe COPD exacerbations within 12 months prior to screening
- • Post-bronchodilator FEV1 ≥ 20% and \< 80% of predicted at screening
- • Post-bronchodilator FEV1/FVC \< 0.70 at screening
- • Modified Medical Research Council (dyspnea scale) (mMRC) score ≥ 2
- • Current tobacco smoker or former smoker with a history of smoking ≥ 10 pack-years
- • On optimized COPD maintenance therapy as defined below for ≥ 12 months prior to screening, and stable on current therapy for at least 4 weeks prior to screening: Inhaled corticosteroid (ICS) plus long-acting beta-agonist (LABA), Long-acting muscarinic antagonist (LAMA) plus LABA, ICS plus LAMA plus LABA
- • Chest X-ray or computed tomography (CT) scan within 6 months prior to screening or chest X-ray during the screening period that confirms the absence of clinically significant lung disease besides COPD
- • Exclusion Criteria
- • Current documented diagnosis of asthma
- • History of clinically significant pulmonary disease other than COPD
- • Diagnosis of 1-antitrypsin deficiency
- • History of long-term treatment with oxygen at \> 4.0 liters/minute
- • Lung volume reduction surgery or procedure within 12 months prior to screening
- • Individuals participating in, or scheduled for, an intensive COPD rehabilitation program (participants who are in the maintenance phase of a rehabilitation program are eligible)
- • History of lung transplant
- • Any infection that resulted in hospital admission for ≥ 24 hours and/or treatment with oral, IV, or IM antibiotics within 4 weeks prior to or during screening
- • Upper or lower respiratory tract infection within 4 weeks prior to or during screening
- • Treatment with oral, IV, or IM corticosteroids within 4 weeks prior to initiation of study drug
- • Initiation of or change in non-biologic immunomodulatory or immunosuppressive therapy within 3 months prior to screening
- • Unstable cardiac disease, myocardial infarction, or New York Heart Association Class III or IV heart failure within 12 months prior to screening
About Hoffmann La Roche
Hoffmann-La Roche, commonly known as Roche, is a global leader in biotechnology and pharmaceuticals, committed to advancing healthcare through innovative research and development. With a strong focus on oncology, immunology, infectious diseases, and central nervous system disorders, Roche leverages cutting-edge science to deliver transformative therapies and diagnostics. The company is dedicated to improving patient outcomes by conducting rigorous clinical trials and collaborating with healthcare professionals and organizations worldwide. Roche's unwavering commitment to precision medicine and personalized healthcare positions it at the forefront of the industry, driving progress in the quest for effective treatments and improved patient care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Adelaide, South Australia, Australia
Pessac, , France
Valencia, , Spain
Hong Kong, , Hong Kong
Vancouver, British Columbia, Canada
Birmingham, Alabama, United States
Newcastle Upon Tyne, , United Kingdom
Valencia, , Spain
Palo Alto, California, United States
Weston, Florida, United States
Burlington, Vermont, United States
Rosenheim, , Germany
Madrid, , Spain
Norwich, , United Kingdom
Vancouver, British Columbia, Canada
Birmingham, Alabama, United States
Dunedin, , New Zealand
Barcelona, , Spain
Leicester, , United Kingdom
Badalona, Barcelona, Spain
Alzira, Valencia, Spain
Portland, Oregon, United States
Tokyo, , Japan
Taipei, , Taiwan
Lancaster, , United Kingdom
Edinburgh, , United Kingdom
Bruxelles, , Belgium
Brussels, , Belgium
Sevilla, , Spain
Haifa, , Israel
Beijing, , China
Houston, Texas, United States
Khon Kaen, , Thailand
Auckland, , New Zealand
Leeds, , United Kingdom
Hiroshima, , Japan
Kiryu, , Japan
Kyoto, , Japan
Quezon City, , Philippines
Seoul, , Korea, Republic Of
Houston, Texas, United States
London, , United Kingdom
Daugavpils, , Latvia
Immenhausen, , Germany
Chattanooga, Tennessee, United States
Chengdu, , China
Bangkok, , Thailand
Louisville, Kentucky, United States
Taipei, , Taiwan
Coventry, , United Kingdom
Mersin, , Turkey
Kanagawa, , Japan
Kyoto, , Japan
Palma De Mallorca, Islas Baleares, Spain
Lucknow, Uttar Pradesh, India
Hong Kong, , Hong Kong
Manila, , Philippines
Hradec Kralove, , Czechia
Taoyuan, , Taiwan
Boerne, Texas, United States
Shenyang, Liaoning, China
Liège, , Belgium
Taipei, , Taiwan
Orlando, Florida, United States
Dunedin, , New Zealand
Berlin, , Germany
Heidelberg, , Germany
Daugavpils, , Latvia
Taipei City, , Taiwan
Goteborg, , Sweden
Milano, Lombardia, Italy
Madrid, , Spain
Hangzhou, Zhejiang, China
Hamburg, , Germany
Cottingham, Yorkshire, United Kingdom
Lexington, Kentucky, United States
Fukuoka, , Japan
Beek, , Netherlands
Beijing, , China
Kitakyushu Shi, , Japan
Quezon City, , Philippines
Houston, Texas, United States
Orlando, Florida, United States
Cottingham, , United Kingdom
Bloemfontein, , South Africa
Rosario, , Argentina
Pergamino, , Argentina
Lipa City, , Philippines
Nanjing, , China
Amersfoort, , Netherlands
Tokyo, , Japan
Seoul, , Korea, Republic Of
New Orleans, Louisiana, United States
Torino, Piemonte, Italy
Pavia, Lombardia, Italy
Hamilton, , New Zealand
Næstved, , Denmark
Saint Louis, Missouri, United States
Cheongju Si, , Korea, Republic Of
Haifa, , Israel
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Dallas, Texas, United States
Daegu, , Korea, Republic Of
Linhai, , China
Xiamen, , China
Buenos Aires, , Argentina
Niigata Shi, , Japan
Sapporo Shi, , Japan
Tauranga, , New Zealand
Craiova, , Romania
Kirikkale, , Turkey
Miami, Florida, United States
San Miguel De Tucuman, , Argentina
Smolyan, , Bulgaria
Veliko Tarnovo, , Bulgaria
Paris, , France
Machida Shi, , Japan
Tokyo, , Japan
Auckland, , New Zealand
Nedlands, Western Australia, Australia
Santa Fe, , Argentina
Santo Andre, Sp, Brazil
München, , Germany
Jerusalem, , Israel
Greensboro, North Carolina, United States
Gastonia, North Carolina, United States
Groningen, , Netherlands
Iloilo City, , Philippines
Xuzhou, , China
Pittsburgh, Pennsylvania, United States
Taipei City, , Taiwan
New Delhi Delhi, Delhi, India
Kocaeli, , Turkey
Groningen, , Netherlands
Guangzhou, Guangdong, China
Sofia, , Bulgaria
Florence, Toscana, Italy
Nanchang, Jiangxi, China
Salt Lake City, Utah, United States
Gdynia, , Poland
Montreal, Quebec, Canada
Wuxi, , China
Herakleion, , Greece
Palermo, Sicilia, Italy
Wonju Si, , Korea, Republic Of
Katowice, , Poland
Pavia, Lombardia, Italy
Wuxi, , China
Catania, Sicilia, Italy
Sakai Shi, , Japan
New Taipei, , Taiwan
Tatabánya, , Hungary
Porto Alegre, Rio Grande Do Sul, Brazil
Beijing, , China
Changchun City, , China
Jerusalem, Yerushalayim, Israel
Farkasgyepu, , Hungary
Zutphen, , Netherlands
Beer Sheva, , Israel
Torrejon De Ardoz, Madrid, Spain
Toledo, Ohio, United States
Vitoria, Es, Brazil
Gabrovo, , Bulgaria
Rosario, , Argentina
Everett, Washington, United States
Columbia, South Carolina, United States
Guangdong, , China
Shanghai, , China
Orbassano, Piemonte, Italy
Chang Hua, , Taiwan
Tianjin, , China
Kfar Saba, , Israel
Ishikawa, , Japan
Wonju Si, , Korea, Republic Of
Darmstadt, , Germany
Hannover, , Germany
Saint Charles Borromee, Quebec, Canada
Nanjing, , China
Kagoshima, , Japan
Bucheon Si,, , Korea, Republic Of
Centurion, , South Africa
Athens, , Greece
Magdeburg, , Germany
Nagpur, Maharashtra, India
Tabor, , Czechia
Gyongyos, , Hungary
Gyeonggi Do, , Korea, Republic Of
Shanghai, , China
Altoona, Pennsylvania, United States
Chikushino Shi, , Japan
Toronto, Ontario, Canada
Windsor, Ontario, Canada
Timisoara, , Romania
Guangzhou, , China
Nanjing City, , China
Las Vegas, Nevada, United States
Balassagyarmat, , Hungary
Roskilde, , Denmark
Beijing City, , China
Ioannina, , Greece
Sofia, , Bulgaria
Tulsa, Oklahoma, United States
Beijing City, , China
Haifa, , Israel
Haikou, , China
Windsor, Ontario, Canada
Altamonte Springs, Florida, United States
Mibu Machi, , Japan
Wroclaw, , Poland
Guangzhou, Guangdong, China
Hangzhou, Zhejiang, China
Pingxiang, , China
Houston, Texas, United States
Zhanjiang, Guangdong, China
Aichi, , Japan
Shizuoka, , Japan
Kaoshiung City, , Taiwan
Changsha, , China
Zunyi, Guizhou, China
Flint, Michigan, United States
Ahmedabad, Gujarat, India
Zigong, , China
Feldbach, , Austria
Kyjov, , Czechia
Joyo, , Japan
Valencia, , Spain
Nantong, , China
Xinxiang, , China
Zunyi, , China
Quillota, , Chile
Bakersfield, California, United States
Brugge, , Belgium
Okinawa, , Japan
Hefei, , China
Beijing, , China
Riga, , Latvia
Rio De Janeiro, , Brazil
Sofia, , Bulgaria
Saint Charles, Missouri, United States
Shumen, , Bulgaria
Rome, Lazio, Italy
Pessac, , France
Walnut Creek, California, United States
Bellevue, Nebraska, United States
Edmond, Oklahoma, United States
Sofia, , Bulgaria
Sofia, , Bulgaria
Mexico, Mexico City (Federal District), Mexico
Franklin, Tennessee, United States
Durham, North Carolina, United States
Sao Bernardo Do Campo, Sp, Brazil
Lübeck, , Germany
Plovdiv, , Bulgaria
Lianyungang, , China
Passo Fundo, Rs, Brazil
Brandon, Florida, United States
Miami, Florida, United States
Napoli, Campania, Italy
Kumamoto Shi, , Japan
Hanoi, , Vietnam
Blagoevgrad, , Bulgaria
Barcelona, , Spain
Corby, , United Kingdom
Houston, Texas, United States
Bydgoszcz, , Poland
Czestochowa, , Poland
Warszawa, , Poland
Birmingham, , United Kingdom
Cardiff, , United Kingdom
Chorley, , United Kingdom
Huntersville, North Carolina, United States
Daugavpils, , Latvia
Sao Bernardo Do Campo, , Brazil
Hubli, Karnataka, India
Windsor, Ontario, Canada
Amiens, , France
Kolkata, West Bengal, India
Csorna, , Hungary
Mobile, Alabama, United States
Lathrup Village, Michigan, United States
Winston Salem, North Carolina, United States
Sosnowiec, , Poland
Passo Fundo, Rio Grande Do Sul, Brazil
Athina, , Greece
Bologna, Emilia Romagna, Italy
The Villages, Florida, United States
New York, New York, United States
Montana, , Bulgaria
Franklin, Tennessee, United States
Ajax, Ontario, Canada
Nairobi, , Kenya
Porto Alegre, Rs, Brazil
Denver, North Carolina, United States
Torun, , Poland
Alexandroupolis, , Greece
Lublin, , Poland
Miami, Florida, United States
Ho Chi Minh City, , Vietnam
Muang, , Thailand
Changsha, , China
Atlanta, Georgia, United States
Guangzhou, , China
R?Ga, , Latvia
Bia?Ystok, , Poland
Greenacres City, Florida, United States
Kanpur, Uttar Pradesh, India
Flint, Michigan, United States
Gaffney, South Carolina, United States
Dothan, Alabama, United States
Bangor, Maine, United States
Berlin, New Jersey, United States
Wroc?Aw, , Poland
Orlando, Florida, United States
Ormond Beach, Florida, United States
Hammond, Indiana, United States
Reno, Nevada, United States
Austin, Texas, United States
Corsicana, Texas, United States
Riga, , Latvia
Porto Alegre, Rio Grande Do Sul, Brazil
Chongqing City, , China
Anniston, Alabama, United States
Birmingham, Alabama, United States
Glendale, Arizona, United States
Glendale, Arizona, United States
Tucson, Arizona, United States
Vista, California, United States
Coconut Creek, Florida, United States
Stonecrest, Georgia, United States
Cincinnati, Ohio, United States
Houston, Texas, United States
Katy, Texas, United States
Tampa, Florida, United States
Miami, Florida, United States
Tampa, Florida, United States
Columbus, Georgia, United States
Huber Heights, Ohio, United States
Hendersonville, Tennessee, United States
Houston, Texas, United States
Trzebnica, , Poland
City Of Johannesburg, , South Africa
Kempton Park, , South Africa
Krugersdorp, , South Africa
Pretoria, , South Africa
Dimitrovgrad, , Bulgaria
Varna, , Bulgaria
Hamburg, , Germany
Debrecen, , Hungary
Riga, , Latvia
Paraparaumu, , New Zealand
Bydgoszcz, , Poland
Bydgoszcz, , Poland
Katowice, , Poland
Krakow, , Poland
Wroc?Aw, , Poland
Zabrze, , Poland
Cluj Napoca, , Romania
Benalmadena Costa, Malaga, Spain
Okayama, , Japan
Johannesburg, , South Africa
Greenfield, Wisconsin, United States
Buenos Aires, , Argentina
Buenos Aires, , Argentina
Mendoza, , Argentina
San Nicolas De Los Arroyos, , Argentina
Opava, , Czechia
Teplice, , Czechia
Berlin, , Germany
Neu Isenburg, , Germany
Rheine, , Germany
Palaio Faliro, , Greece
Thessaloniki, , Greece
Heerlen, , Netherlands
Chojnice, , Poland
Grudzadz, , Poland
Ksawerów, , Poland
Lodz, , Poland
Lublin, , Poland
Radom, , Poland
Sopot, , Poland
Szczecin, , Poland
Tarnow, , Poland
Wroc?Aw, , Poland
Zurich, , Switzerland
Heraklio, , Greece
Cz?Stochowa, , Poland
Gda?Sk, , Poland
Buenos Aires, , Argentina
Buenos Aires, , Argentina
Ciudad Autonoma Buenos Aires, , Argentina
Ciudad Autonoma De Buenos Aires, , Argentina
Concepcion Del Uruguay, , Argentina
Parana, , Argentina
Ranelagh, Berazategui, , Argentina
Rosario, , Argentina
San Salvador, , Argentina
Santa Fe, , Argentina
Linz, , Austria
Pavie Gallegos, , Chile
Vina Del Mar, , Chile
Vitacura, , Chile
Leipzig, , Germany
Athens, , Greece
Pretoria, , South Africa
Somerset West, , South Africa
Linköping, , Sweden
Solna, , Sweden
Stockholm, , Sweden
Dubois, Pennsylvania, United States
Schenectady, New York, United States
Las Vegas, Nevada, United States
Fayetteville, North Carolina, United States
Mauldin, South Carolina, United States
Houston, Texas, United States
Midlothian, Virginia, United States
Cordoba, , Argentina
Entre Rios, , Argentina
La Plata, , Argentina
Sofia, , Bulgaria
Varna, , Bulgaria
Edmonton, Alberta, Canada
Teplice, , Czechia
Berlin, , Germany
Timisoara, , Romania
Ponferrada, Leon, Spain
Linkoping, , Sweden
Uppsala, , Sweden
Troy, Michigan, United States
Berlin, , Germany
Bellshill, , United Kingdom
Manchester, , United Kingdom
Ciudad Autonoma De Buenos Aires, , Argentina
Silistra, , Bulgaria
Brandys Nad Labem Stara Boleslav, , Czechia
Vandoeuvre, , France
Frankfurt, , Germany
Frankfurt, , Germany
Leipzig, , Germany
Machakos, , Kenya
Grudziadz, , Poland
Lodz, , Poland
Chesterfield, , United Kingdom
Hexham, , United Kingdom
Belo Horizonte, Mg, Brazil
Miami, Florida, United States
Birmingham, Alabama, United States
Longwood, Florida, United States
Miami, Florida, United States
Farmington Hills, Michigan, United States
Houston, Texas, United States
La Plata, , Argentina
La Plata, , Argentina
Brasilia, Df, Brazil
Rio De Janeiro, Rj, Brazil
Sao Paulo, Sp, Brazil
Razgrad, , Bulgaria
Sherwood Park, Alberta, Canada
Quebec, , Canada
Huizhou, , China
Praha 1, , Czechia
Praha, , Czechia
Srikakulam, Andhra Pradesh, India
Faridabad, Haryana, India
Hubli, Karnataka, India
Nagpur, Maharashtra, India
Ajmer, Rajasthan, India
Jaipur, Rajasthan, India
Hyderabad, Telangana, India
Lucknow, Uttar Pradesh, India
Hastings, , New Zealand
Slupsk, , Poland
Guaynabo, , Puerto Rico
Orebro, , Sweden
Edgbaston, , United Kingdom
Liverpool, , United Kingdom
Santa Fe, , Argentina
Toyama Shi, , Japan
Little Rock, Arkansas, United States
Beijing, , China
Wuxi, , China
Zigong, , China
Daugavpils, , Latvia
Iloilo City, , Philippines
Quezon City, , Philippines
Montreal, Quebec, Canada
Istanbul, , Turkey
Hyderabad, Andhra Pradesh, India
Cheongju Si, , Korea, Republic Of
Chengdu, , China
Yangzhou, , China
Ahmadabad City, Gujarat, India
Pune, Maharashtra, India
Ferrara, Emilia Romagna, Italy
Chuo, , Japan
Himeji, , Japan
Shizuoka, , Japan
Takamatsu, , Japan
Yanagawa, , Japan
Dasmarinas, , Philippines
Tarnow, , Poland
Welkom, , South Africa
High Wycombe, , United Kingdom
London, , United Kingdom
Guaynabo, , Puerto Rico
Jaipur, Rajasthan, India
Xian, , China
Porto Alegre, Rs, Brazil
Botucatu, Sp, Brazil
Chongqing, , China
Wuhan, , China
New Delhi, Delhi, India
Pune City, Maharashtra, India
Siena, Toscana, Italy
Himeji, , Japan
Kilifi, , Kenya
Nairobi, , Kenya
Siaya, , Kenya
Thika, , Kenya
Caloocan City, , Philippines
Rize Merkez, , Turkey
Saricam, , Turkey
Lancaster, California, United States
Gainesville, Florida, United States
Lathrup Village, Michigan, United States
Madison Heights, Michigan, United States
Saint Louis, Missouri, United States
North Plainfield, New Jersey, United States
Bronx, New York, United States
Pittsburgh, Pennsylvania, United States
Desoto, Texas, United States
Zhuhai City, , China
Brno, , Czechia
Lille, , France
Budapest, , Hungary
Ahmadabad City, Gujarat, India
Nagpur, Maharashtra, India
Battipaglia, Campania, Italy
Reggio Emilia, Emilia Romagna, Italy
Fukuoka Shi Nishi Ku, , Japan
Kawachinagano Shi, , Japan
Kishiwada, , Japan
Koto, , Japan
Mie, , Japan
Oita, , Japan
Okayama Shi Minami Ku, , Japan
Omuta, , Japan
Sagamihara Shi Minami Ku, , Japan
Sapporo Shi Chuo Ku, , Japan
Takasaki, , Japan
Tanabe, , Japan
Yokohama Shi Aoba Ku, , Japan
Oaxaca De Juárez, Mexico City (Federal District), Mexico
Queretaro, , Mexico
Sosnowiec, , Poland
City Of Cape Town, , South Africa
Roodepoort, , South Africa
Ho Chi Minh City, , Vietnam
Las Vegas, Nevada, United States
Beijing City, , China
Asahikawa Shi, , Japan
Chikushino Shi, , Japan
Miyagi, , Japan
Nagoya Shi Minami Ku, , Japan
Yokohama Shi Totsuka Ku, , Japan
Yonezawa, , Japan
New Orleans, Louisiana, United States
Edeleny, , Hungary
Gödöll?, , Hungary
Hajdunanas, , Hungary
Komlo, , Hungary
Sakaide, , Japan
Yokohama Shi Kanazawa Ku, , Japan
Lodz, Lódzkie, Poland
Edmonton, Alberta, Canada
Ciudad Autonoma Buenos Aires, , Argentina
Ciudad Autonoma Buenos Aires, , Argentina
Ciudad Autonoma De Buenos Aires, , Argentina
Sakai Shi, , Japan
Washington, Connecticut, United States
East Brunswick, New Jersey, United States
Buffalo, New York, United States
New Hyde Park, New York, United States
Berazategui, , Argentina
Ciudad Autonoma Buenos Aires, , Argentina
Ciudad Autonoma Buenos Aires, , Argentina
Concepcion Del Uruguay, , Argentina
La Plata, , Argentina
Mendoza, , Argentina
Parana, , Argentina
Rosario, , Argentina
San Miguel De Tucuman, , Argentina
Santiago, , Chile
Leipzig, , Germany
Santo Andre, São Paulo, Brazil
Vitoria, Espírito Santo, Brazil
Ginowan Shi, Okinawa, Japan
Belo Horizonte, Minas Gerais, Brazil
Phoenix, Arizona, United States
Houston, Texas, United States
Buenos Aires, , Argentina
Ciudad Autónoma De Buenos Aires, , Argentina
Mendoza, , Argentina
Parana, , Argentina
Rosario, , Argentina
Midland, South Australia, Australia
Brasilia, Distrito Federal, Brazil
Botucatu, São Paulo, Brazil
Sao Bernardo Do Campo, São Paulo, Brazil
Sao Paulo, São Paulo, Brazil
Hefei City, , China
Hyderabad, Andhra Pradesh, India
New Delhi, Delhi, India
Hubballi, Karnataka, India
Aligarh, Uttar Pradesh, India
Yonezawa, , Japan
Riga, , Latvia
Waikanae Beach, , New Zealand
Kaoshiung City, , Taiwan
Edmond, Oklahoma, United States
Bellevue, Nebraska, United States
Lübeck, Schleswig Holstein, Germany
Berlin, , Germany
Chuo Ku, Fukuoka Shi, , Japan
Naka Gun, , Japan
Kilifi, Coast, Kenya
Pretoria, , South Africa
Marlton, New Jersey, United States
Shanghai, , China
São Paulo, , Brazil
Mangaung, Free State, South Africa
City Of Johannesburg, Gauteng, South Africa
Lianyungang, Jiangsu, China
Budapest, Pest, Hungary
Hubballi, Karnataka, India
Shizuoka, , Japan
Santo Andre, , Brazil
Vitoria, , Brazil
Botucatu, , Brazil
Patients applied
Trial Officials
Clinical Trials
Study Director
Hoffmann-La Roche
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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