Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery

Launched by UNIVERSITY HOSPITAL, BASEL, SWITZERLAND · Oct 24, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how personalized cardiac anesthesia and monitoring of blood flow to the brain can affect the risk of neurological problems after heart surgery. Researchers want to find out if patients whose blood pressure goes outside of a safe range during surgery are more likely to experience issues like confusion, stroke, or memory problems afterward. They will also look at how certain biological markers and genetic factors might relate to these neurological outcomes.

To participate in this study, you need to be scheduled for elective heart surgery, such as a bypass or valve surgery, that requires a heart-lung machine. Unfortunately, if you are having emergency surgery, a transplant, or certain types of surgeries that involve deep cooling of the body, you won’t be eligible. If you join the study, you'll have your blood pressure and brain blood flow monitored during your surgery, and researchers will follow up with you afterward to check on your recovery. This study is currently recruiting participants, so if you meet the criteria, there may be an opportunity for you to contribute to important research in this area.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Elective primary or reoperative coronary artery bypass graft and/or valvular and/or ascending aorta surgery requiring cardiopulmonary bypass.
• Exclusion Criteria:
• • Surgery requiring moderate or deep hypothermic circulatory arrest;
• • Heart and/or lung transplantation;
• • Urgent (\< 24 hours) and emergency surgery;
• • Inability to follow procedures or insufficient knowledge in English, German or French;
• • Inability to give consent.
• • Participants from the University Hospital Basel who undergo cardiac surgery under minimal extracorporeal circulation will also be excluded.