Iodine Uptake After a Low Iodine Diet

Launched by UNIVERSITY MEDICAL CENTER GRONINGEN · Oct 25, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how a low iodine diet (LID) affects the way the thyroid absorbs iodine in patients with differentiated thyroid cancer (DTC). Specifically, the researchers want to see the difference in iodine uptake before and after participants follow a 7-day low iodine diet, using a low dose of radioactive iodine for measurement. This information is important because it helps doctors understand how effective the diet is in preparing patients for further treatment, such as radioactive iodine therapy.

To participate in this trial, individuals must be at least 18 years old, diagnosed with differentiated thyroid cancer, and able to follow the study guidelines. They also need to be able to understand Dutch. Some people may not be eligible, such as those under 18, those taking certain medications, or those with kidney problems. If you join the study, you can expect to follow the low iodine diet for a week and then have your iodine uptake measured before and after this diet. This research is currently recruiting participants and aims to gather valuable insights for better treatment strategies.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients, men and women above the age of 18 years, have to be diagnosed with DTC and have to follow a LID prior to the 131I ablation therapy according to the Dutch DTC guideline
• • Patients have to be fit to adhere to the study protocol
• • Patients have to be able to read and understand the Dutch language
• Exclusion Criteria:
• • Age \< 18 years
• • Patients using amiodarone
• • Patients receiving iodinated contrast \< 3 months before the LID
• • Pregnancy
• • Patients prepared for ablation therapy with rhTSH
• • Renal impairment, EGFR \<30ml/min/1,73m2