Multi Center Observation of Sentinel Skin Graft for Detecting Acute Rejection After Renal Transplantation

Launched by SECOND AFFILIATED HOSPITAL, SCHOOL OF MEDICINE, ZHEJIANG UNIVERSITY · Oct 27, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a new method to help detect if a kidney transplant is being rejected by the body. Researchers are looking at using small skin grafts taken from the same donor as the kidney to see how well they can tell if the transplanted kidney is being rejected. The goal is to find better ways to diagnose kidney transplant rejection early, which can help doctors start treatment sooner if needed.

To participate in this study, you need to be between 18 and 60 years old and have serious kidney disease that requires a kidney transplant. You will need to attend follow-up appointments regularly after your surgery for the first year, which includes weekly visits initially, then less frequent visits as time goes on. It’s important that you agree to participate and understand what the study involves. However, this trial is not for everyone—people with certain health issues, like untreated cancer or serious heart problems, cannot join. If you're interested in learning more or think you might qualify, talk to your doctor.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with end-stage renal disease undergoing renal transplantation;
• • 2. 18-60 years old;
• • 3. Postoperative follow-up points are complete (visit the hospital every week in the first month after surgery, every two weeks in 2-3 months, every four to six months, and every three months in 7-12 months. Follow up at any time when skin rejection is observed. The follow-up time may be adjusted when the condition changes);
• • 4. The participants had good compliance, volunteered to participate in the test and signed the informed consent form.
• Exclusion Criteria:
• • 1. Untreated or disseminated malignant tumor;
• • 2. Active period of infectious diseases;
• • 3. Serious cardiovascular disease occurred recently;
• • 4. Combined with other important organ failure;
• • 5. History of mental illness or cognitive impairment;