Influence of Diabetic Control on the Degree of Liver Fibrosis Assessed by Non-invasive Scores in Patients Followed in Diabetology

Launched by FONDATION HÔPITAL SAINT-JOSEPH · Oct 31, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at how well controlling type 2 diabetes affects liver health, specifically the level of liver fibrosis, which is a scarring process that can happen due to liver damage. The study will use non-invasive tests to measure liver fibrosis in patients with type 2 diabetes, as many people with this condition also have fatty liver disease. The researchers want to see if better management of diabetes can help reduce liver damage and improve overall health outcomes.

To participate in this trial, individuals must be at least 18 years old and diagnosed with type 2 diabetes. Patients should be French-speaking and have certain health information available, such as blood sugar levels over the last five years. Participants can expect to undergo tests that assess their liver health without any invasive procedures. The trial is not yet recruiting, but it aims to gather important information that could help doctors better manage diabetes and its related liver complications in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient with age ≥ 18 years
• • Patient with a diagnosis of type 2 diabetes, identified by ICD-10 codes, among patients hospitalized between 01/03/2018 and 17/03/2020 in HDJ in the Diabetes Service of GHPSJ
• • French-speaking patient
• Exclusion Criteria:
• • Absence of at least one HbA1c measurement per year available over a period of 5 years (This is obtained by different means: handwritten in the patient's file, performed in the HDJ, performed in town and integrated into the patient's file, reported orally by the patient during the follow-up consultation. Glycated hemoglobin data for the 5-year retrospective period available).
• • Lack of sufficient data to calculate the non-invasive fibrosis score FIB4.
• • Secondary diabetes (neoplasia, chronic calcifying pancreatitis, post pancreatectomy pancreatic insufficiency for various reasons: see figure 8 below)
• • HDJ for pre-bariatric surgery evaluation
• • Other declared causes of chronic liver disease according to the patient's medical record
• • Patient under guardianship or curatorship
• • Patient deprived of liberty
• • Patient under court protection
• • Patient objecting to the use of his/her data for this research