Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

Launched by DARTMOUTH-HITCHCOCK MEDICAL CENTER · Nov 4, 2022

Keywords

ClinConnect Summary

This clinical trial is comparing two methods for monitoring older adults who have had colon polyps: annual stool testing (called FIT) and colonoscopy. It focuses on adults aged 65 to 82 who have a history of non-advanced colorectal polyps and are due for a follow-up colonoscopy. The goal is to see which method is more effective for keeping track of their health and preventing colorectal cancer.

To participate in this trial, you should be fluent in English or Spanish and have a personal history of colorectal polyps, with your last colonoscopy showing no more than two non-advanced polyps. You also need to be scheduled for a colonoscopy within the next year. However, if you have had colorectal cancer, certain genetic syndromes that increase cancer risk, or other serious health issues, you may not be eligible. Participants will receive either the stool test or a colonoscopy, helping researchers determine the best approach for monitoring this group of patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • English or Spanish speaking
• • Personal history of colorectal polyps
• • Most recent colonoscopy with ≤2 non-advanced polyps
• • Currently due or coming due within 12 months for colonoscopy
• • Able to provide written informed consent
• Exclusion Criteria:
• • Personal history of colorectal cancer
• • Personal history of genetic syndrome with high risk for colorectal cancer (e.g. Lynch Syndrome, Familial Adenomatous Polyposis Syndrome (FAP), or Serrated Polyposis Syndrome)
• • Personal history of inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease)
• • Most recent colonoscopy with advanced polyp(s) or ≥3 non-advanced polyps
• • Patients unlikely to benefit from polyp surveillance (e.g., history of heart disease or coronary artery disease with treatment in the last 6 months, heart failure affecting function, lung disease requiring use of home oxygen, stroke within the last 4 months, dementia affecting activities of daily living (ADL) or instrumental activities of daily living (IADL), severe liver disease requiring the use of certain medications to control fluid, confusion, or bleeding, severe kidney disease requiring dialysis, or a new cancer diagnosis within the last year)
• • Patients unable to provide written informed consent