Improve Outcomes for Older Allogeneic Transplant Recipients

Launched by ABRAMSON CANCER CENTER AT PENN MEDICINE · Nov 8, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating whether a supervised exercise program can help improve health outcomes for older adults undergoing a specific type of stem cell transplant called allogeneic hematopoietic cell transplantation (HCT). The study aims to see if it is feasible to implement this exercise program for participants, with plans to enroll around 60 to 72 people who will actively take part in the exercise intervention.

To be eligible for the trial, participants must be 60 years or older and have a planned allogeneic HCT either in the next 1-6 months or have recently undergone the procedure within the last 30 days. They must also have a blood cancer that requires the transplant and be considered pre-frail or frail based on a specific assessment. Unfortunately, those with other serious health issues that would make exercise unsafe cannot participate. If you join the study, you can expect to engage in supervised exercise sessions designed to support your health during this important time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Cohort A (Prehab)
• • 1. Age 60 years or older.
• • 2. Planned allogeneic HCT in the next 1-6 months.
• • 3. Hematological malignancy as the indication for HCT.
• • 4. Pre-frail or frail by Fried frailty phenotype.
• • Cohort B (Rehab)
• • 1. Age 60 years or older.
• • 2. Planned allogeneic HCT or HCT within the last 30 days.
• • 3. Hematological malignancy as the indication for HCT.
• Exclusion Criteria:
• • Cohorts A and B
• • 1. Comorbid disability or illness that prevents safe exercise.