Discover the Immune Signature of Sepsis Caused by Acute Pulmonary Infection: A Cohort Study

Launched by CAPITAL MEDICAL UNIVERSITY · Nov 8, 2022

Keywords

ClinConnect Summary

This clinical trial is looking to learn more about how our immune system responds to infections in the lungs, particularly when caused by viruses like influenza or when someone develops sepsis, a serious condition that can happen when the body reacts poorly to infection. The researchers want to understand the differences in immune responses among patients with viral sepsis, bacterial sepsis, and viral pneumonia. This information could help doctors provide better care for people suffering from these conditions.

To participate in this study, individuals need to be at least 18 years old and have pneumonia confirmed by a chest image. They should also have developed pneumonia within the last eight days and be able to give informed consent. However, certain patients will not be eligible, including those with severe breathing problems, liver disease, or kidney issues, among other health concerns. If someone joins the trial, they can expect to provide information about their health and undergo tests to help researchers understand their immune responses better. This study is not yet recruiting participants, but it aims to enhance our understanding of how the body fights infections in the lungs.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥18 years at time of signing Informed Consent Form
• • 2. chest imaging confirmed pneumonia.
• • 3. Informed consent is obtained
• • 4. The pneumonia onset ≤8 days
• Exclusion Criteria:
• • 1. SaO2/SPO2≤94% on room air or Pa02/Fi02 ratio \<300mgHg before the onset of pneumonia
• • 2. Severe liver disease (e.g. Child Pugh score ≥ C, AST\>5 times upper limit)
• • 3. Patients with known severe renal impairment (estimated glomerular filtration rate ≤30 mL/min/1.73 m2) or receiving continuous renal replacement therapy, hemodialysis,peritoneal dialysis）
• • 4. Pregnant Or Lactating Women
• • 5. Patients were eligible for organ transplantation or had undergone previous organ transplantation surgery
• • 6. HIV infection
• • 7. Had unstable angina or myocardial infarction within 30 days without vascular recanalization treatment