Effectiveness of Antibiotic Prophylaxis of Infective Endocarditis for Invasive Dental Procedures in Patients With Prosthetic Heart Valves and/or History of Infective Endocarditis

Launched by UNIVERSITY HOSPITAL, BORDEAUX · Nov 8, 2022

Keywords

ClinConnect Summary

This clinical trial is studying whether giving antibiotics before certain dental procedures can help prevent a serious heart infection called infective endocarditis (IE) in patients who have prosthetic heart valves or a history of IE. Researchers want to see if taking these antibiotics can lower the chances of developing this infection after dental work. They will gather information from different health regions in France and analyze how dental practices might change as a result of the findings.

To be eligible for this study, participants need to be at least 18 years old and have either a prosthetic heart valve or a history of infective endocarditis. Dentists from various health territories will also be involved in the study. While the trial is not yet recruiting participants, those who join can expect to contribute to important research that could influence how dental care is provided to patients at risk for this infection.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All French Health Territories (Territoires de santé, TDS) will be included and each TDS will contribute as a cluster for randomization.
• • All dentists working in each TDS will be included.
• • Among individuals receiving an invasive dental procedure, all patients aged 18 years or more identified with prosthetic heart valves or recorded with prior infective endocarditis will be included.
• Exclusion Criteria:
• • No exclusion criteria for health territories, dentists and patient.
• • However, dental procedures that had been performed less than 6 months after the date of first implantation of prosthetic heart valve won't be included.