Ketotifen in Non-Alcoholic Fatty Liver Disease Patients

Launched by TANTA UNIVERSITY · Nov 13, 2022

Keywords

ClinConnect Summary

Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation and deposition of fats in the hepatocytes which affect the liver structure and function. Causes of NAFLD vary but mainly attributed to dyslipidemia and obesity. Prevalence of NAFLD has been raised over years from 25% in 2005 to over 37% in 2016 and continues to increase to become one of the most common chronic liver disease (Li J et al., 2019).

The disease progress from steatosis and inflammatory infiltration that is known as nonalcoholic steatohepatitis (NASH) to liver fibrosis, cirrhosis, and ultimately hepatoc...

Gender

ALL

Eligibility criteria

• • -Inclusion criteria: Adult males or females aged ≥18 years.
• • All patients are diagnosed to have fatty liver grading 1, 2 or 3 on abdominal ultrasound with Hepatic steatosis index \> 36 to be considered as a NAFLD patient.
• • Confirmed diagnosis of NASH
• * Exclusion Criteria:
• • Current or history of significant alcohol consumption.
• • Use of drugs historically associated with nonalcoholic fatty liver disease (NAFLD) (amiodarone, methotrexate, systemic glucocorticoids, tetracyclines, tamoxifen, estrogens at doses greater than those used for hormone replacement, anabolic steroids, valproic acid, and other known hepatotoxins).
• • Prior or planned bariatric surgery.
• • Uncontrolled diabetes defined as Hemoglobin A1c 9.5% or higher.
• • Evidence of other forms of chronic liver disease as Hepatitis B, Hepatitis C, Wilson's disease, Alpha-1-antitrypsin (A1AT) deficiency, Hemochromatosis, drug-induced liver disease.
• • Pregnancy, planned pregnancy, potential for pregnancy and unwillingness to use effective birth control during the trial and breast feeding.
• • Use of other drugs known to have possible positive effects on steatosis.
• • Other anti-histaminic, sedating agents (CNS depressants) and anticholinergic medications.