Oral Dexmedetomidine in Pediatric MRI

Launched by CHILDREN'S MERCY HOSPITAL KANSAS CITY · Nov 16, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating the use of a medication called oral dexmedetomidine to help children relax while they undergo an MRI scan. The goal is to see if this medication can be effective as the only sedative for young patients, making the MRI process easier and safer for them.

Children between the ages of 3 to 6 years old who need an MRI with general anesthesia may be eligible to participate in this study. However, some children will not be able to take part if they have certain medical conditions, allergies, or if they cannot take the medication at least 90 minutes before the MRI. If eligible, participants will receive oral dexmedetomidine prior to the scan, and the researchers will monitor how well it works. This study aims to improve sedation options for young patients during MRI procedures, helping to ensure a smoother experience for both the child and their family.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Participants 3-6 years old, male and female, all races and ethnicities
• • 2. Requiring a clinically indicated MRI with general anesthesia
• Exclusion Criteria:
• • 1. Refusal to take oral dexmedetomidine
• • 2. Known allergy to dexmedetomidine
• • 3. Inability to take dexmedetomidine at least 90 minutes prior to start of the MRI
• 4. Medical contraindications to administration of dexmedetomidine including:
• • 1. Unstable cardiac status including life threatening arrhythmias, abnormal cardiac anatomy, significant cardiac dysfunction
• • 2. Current use of digoxin
• • 3. Moya Moya disease
• • 4. New onset stroke
• • 5. American Society of Anesthesiologists (ASA) physical status classification \> II
• 6. Contraindications to administering sedation including:
• • 1. Active and uncontrolled gastroesophageal reflux
• • 2. Active and uncontrolled vomiting
• • 3. Current or recent history of apnea
• • 4. Active respiratory disease including pneumonia, bronchitis, respiratory syncytial virus infection, asthma exacerbation
• • 5. Craniofacial anomalies
• • 7. Inability to have MRI scans
• • 8. Non-English speaking volunteers