Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment

Launched by JOHANNES KEPLER UNIVERSITY OF LINZ · Nov 16, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to quickly diagnose and manage keratitis, which is an infection of the cornea in the eye that can be caused by bacteria or fungi. The researchers want to see how certain proteins in the body, known as cytokines, can help identify the types of germs causing the infection. They also aim to create a decision-making tool that will help doctors determine the best treatment based on the specific type of keratitis a patient has.

To participate in this study, you need to be at least 18 years old and have recently developed keratitis that hasn’t responded to treatment or has just appeared within the last 10 days. You will need to give your written permission to join the study. If you have had symptoms for more than 10 days, are pregnant, or have a serious health condition, you may not be eligible. Participants can expect to undergo non-invasive tests that will help with the rapid assessment of their condition, making it easier for doctors to provide the right care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men and women age of at least 18 years to 119 years
• • Written informed consent prior to study-related procedures
• • First presentation with keratitis (corneal epithelial ulceration, corneal edema and/or stromal infiltration with inflammatory cells) within 10 days.
• • Untreated keratitis or keratitis not responding to the given treatment
• Exclusion Criteria:
• Subjects will be excluded if one or more of the following criteria apply:
• • Symptoms for more than 10 days
• • Presence or history of a severe medical condition as judged by the clinical investigator
• • Pregnancy, planned pregnancy or lactating