Erector Spinae Plane Block Improves Organ Dysfunction in Septic Patients With Acute Gastrointestinal Injury

Launched by JING CAI, MD · Nov 18, 2022

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ClinConnect Summary

This clinical trial is studying a technique called the erector spinae plane block to see if it can help improve organ function in patients who have sepsis and acute gastrointestinal injury. Sepsis is a serious condition caused by infections that can lead to problems with organ function, and acute gastrointestinal injury (AGI) can make this worse. The researchers aim to find out if using this block can help these patients recover better while they are in the intensive care unit (ICU).

To participate in the trial, individuals need to be over 18 years old and diagnosed with sepsis and AGI grades II or III. They should also be expected to stay in the ICU for at least three days. However, some people may not be eligible, such as those with certain heart issues, recent surgeries, or specific medical conditions that could complicate the procedure. If someone joins the study, they can expect to receive the erector spinae plane block as part of their treatment and will be monitored closely for improvements in their organ function during their ICU stay.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Septic patients with acute gastrointestinal injury grade II or III;
• • Age over 18 years;
• • Expected to stay in the ICU for at least 3 days or longer;
• Exclusion Criteria:
• • Mean arterial pressure less than 65 mmHg after fluid resuscitation, or requirement for an intravenous norepinephrine dose of greater than 0.5 µg/kg/min to maintain a normal mean arterial pressure;
• • Heart rates less than 50 beats/min, or concomitant with moderate-to-severe atrioventricular block without a pacemaker;
• • Contraindications for erector spinae plane blocks, including infection of the puncture site, spinal diseases or immobilization;
• • Primary gastrointestinal disorders requiring a surgical procedure, such as mechanical intestinal obstruction, massive gastrointestinal hemorrhage, and gastrointestinal perforation;
• • Gastrointestinal operation within one week before enrollment;
• • Neuromuscular disorders;
• • Coagulation abnormalities：activated prothrombin time or prothrombin time is prolonged with 2 folds, or platelet count less than 50×109/L;
• • End-stage malignant tumor or cachexia;
• • History of allergy to amide anesthetics;
• • Known pregnancy;