Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
Launched by ASTRAZENECA · Nov 18, 2022
Trial Information
Current as of August 21, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a new medication called tozorakimab to see how well it works for adults who are hospitalized with a viral lung infection and need extra oxygen. The main goal is to find out if adding tozorakimab to the standard care can help prevent patients from getting worse or dying. This is important because some patients with viral lung infections can develop serious problems that require more intensive treatment, like being put on a breathing machine.
To be eligible for this trial, participants need to be at least 18 years old and must be hospitalized with a viral lung infection that is causing low oxygen levels in their blood. This is determined by certain tests, like how much oxygen is in their blood and whether they show signs of needing help to breathe. The trial is currently looking for all adult patients who meet these criteria. If someone joins the trial, they will receive either the new medication or a placebo (a treatment that looks like the real one but has no active ingredients), along with the usual care for their condition. It's a chance to contribute to research that could improve treatment for viral lung infections in the future.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Adult participants ≥ 18 years old at the time of signing the informed consent form.
- • Patients hospitalised with viral lung infection.
- • Hypoxaemia requiring treatment with supplemental O2.
- Hypoxaemia is defined as:
- • SpO2 ≤ 90% OR
- SpO2 ≤ 92% AND one or both of the following:
- • Radiographic infiltrates by CXR/CT compatible with viral lung infection per investigator judgement.
- • Use of accessory muscles of respiration or RR (respiratory rate) \> 22.
- • - Patient remains hypoxaemic at randomisation requiring treatment with supplemental oxygen.
- Exclusion Criteria:
- • Known fungal or parasitic lung infection, aspiration lung infection, lung abscess, or evidence of septic shock. Bacterial co-infection is allowed, unless, in the opinion of the investigator, bacterial infection defines the severity of the participant's condition.
- • Hypoxaemia caused primarily by extrapulmonary insult or by lung injury of non-infective aetiology.
- • Ongoing IMV/ECMO at randomisation.
About Astrazeneca
AstraZeneca is a global biopharmaceutical company dedicated to the discovery, development, and commercialization of innovative medicines across various therapeutic areas, including oncology, cardiovascular, respiratory, and autoimmune diseases. With a strong commitment to scientific research and patient-centric solutions, AstraZeneca leverages cutting-edge technology and a robust pipeline to address unmet medical needs. The company collaborates with healthcare professionals, academic institutions, and other organizations to advance clinical trials and deliver transformative therapies, aiming to improve health outcomes and enhance the quality of life for patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Houston, Texas, United States
Charlottesville, Virginia, United States
Hong Kong, , Hong Kong
Varna, , Bulgaria
Detroit, Michigan, United States
Praha 10, , Czechia
Nyíregyháza, , Hungary
Mexico City, , Mexico
Malaga, , Spain
Denver, Colorado, United States
Iloilo City, , Philippines
Louisville, Kentucky, United States
New York, New York, United States
Columbus, Ohio, United States
Berlin, , Germany
Kiel, , Germany
Barcelona, , Spain
Portland, Oregon, United States
Roeselare, , Belgium
Yvoir, , Belgium
Toronto, Ontario, Canada
Jerusalem, , Israel
Napoli, , Italy
Phoenix, Arizona, United States
Evanston, Illinois, United States
New Orleans, Louisiana, United States
Roma, , Italy
Barcelona, , Spain
Dundee, , United Kingdom
Iowa City, Iowa, United States
Baton Rouge, Louisiana, United States
Oklahoma City, Oklahoma, United States
Strasbourg, , France
Hannover, , Germany
Regensburg, , Germany
Athens, , Greece
Málaga, , Spain
Oxford, , United Kingdom
Boise, Idaho, United States
Rehovot, , Israel
Madrid, , Spain
Chicago, Illinois, United States
Kansas City, Kansas, United States
Worcester, Massachusetts, United States
Debrecen, , Hungary
Levis, Quebec, Canada
Mobile, Alabama, United States
Annapolis, Maryland, United States
Saint Louis, Missouri, United States
Winston Salem, North Carolina, United States
Philadelphia, Pennsylvania, United States
Pleven, , Bulgaria
Montreal, Quebec, Canada
Benesov, , Czechia
Hvidovre, , Denmark
Hamburg, , Germany
Haifa, , Israel
Holon, , Israel
Arezzo, , Italy
Sibiu, , Romania
Timisoara, , Romania
Leeds, , United Kingdom
Leicester, , United Kingdom
Atlanta, Georgia, United States
Los Angeles, California, United States
Aguascalientes, , Mexico
Washington, District Of Columbia, United States
Lakeland, Florida, United States
Kortrijk, , Belgium
Ottignies, , Belgium
Augsburg, , Germany
Marburg, , Germany
München, , Germany
Ioannina, , Greece
Thessaloniki, , Greece
London, , United Kingdom
Brescia, , Italy
Shreveport, Louisiana, United States
Houston, Texas, United States
Ottawa, Ontario, Canada
Ramat Gan, , Israel
Lund, , Sweden
Providence, Rhode Island, United States
Miami, Florida, United States
Greenville, North Carolina, United States
Quezon City, , Philippines
Manila, , Philippines
Taichung, , Taiwan
Taipei, , Taiwan
Bangkok, , Thailand
Chiang Mai, , Thailand
Saskatoon, Saskatchewan, Canada
Valencia, , Spain
Adelaide, , Australia
South Brisbane, , Australia
Brno, , Czechia
Springfield, Massachusetts, United States
Phoenix, Arizona, United States
Jacksonville, Florida, United States
Ruse, , Bulgaria
New Delhi, , India
New Delhi, , India
Bratislava, , Slovakia
Warszawa, , Poland
Sioux Falls, South Dakota, United States
El Paso, Texas, United States
Green Bay, Wisconsin, United States
Beijing, , China
Shanghai, , China
Athens, , Greece
Taichung, , Taiwan
Sofia, , Bulgaria
Brest Cedex, , France
Rozzano, , Italy
Roma, , Italy
Hradec Kralove, , Czechia
Budapest, , Hungary
London, , United Kingdom
Majadahonda, , Spain
Phoenix, Arizona, United States
Fort Wayne, Indiana, United States
Brooklyn, New York, United States
Fresno, California, United States
Newport Beach, California, United States
Elmhurst, Illinois, United States
Corvallis, Oregon, United States
Bayamon, , Puerto Rico
Kyoto Shi, , Japan
Mitaka Shi, , Japan
Ubonratchathani, , Thailand
Herning, , Denmark
Vejle, , Denmark
Dijon, , France
La Mesa, California, United States
Torrance, California, United States
Campinas, , Brazil
Sliven, , Bulgaria
Chongqing, , China
Yinchuan, , China
Pécs, , Hungary
Kuala Lumpur, , Malaysia
Cebu, , Philippines
łęczna, , Poland
Parktown, , South Africa
Soweto, , South Africa
Kaohsiung, , Taiwan
Salt Lake City, Utah, United States
Glasgow, , United Kingdom
Observatory, , South Africa
Aalborg, , Denmark
Amiens Cedex 1, , France
Colorado Springs, Colorado, United States
Stockholm, , Sweden
Umeå, , Sweden
Malmö, , Sweden
Pamplona, , Spain
Milwaukee, Wisconsin, United States
Chula Vista, California, United States
Chengdu, , China
Suita Shi, , Japan
Monterrey, , Mexico
Kistarcsa, , Hungary
Royal Oak, Michigan, United States
Gainesville, Florida, United States
Leverkusen, , Germany
Odense C, , Denmark
Montpellier Cedex 5, , France
Saint Petersburg, Florida, United States
São José Do Rio Preto, , Brazil
Quebec, , Canada
Nanchang, , China
Kasuga Shi, , Japan
Yokohama Shi, , Japan
Chrzanów, , Poland
Košice, , Slovakia
Hanoi, , Vietnam
Fresno, California, United States
Winnipeg, Manitoba, Canada
La Tronche, , France
Le Coudray Cedex, , France
Meguro Ku, , Japan
Shinjuku Ku, , Japan
Ankara, , Turkey
Malatya, , Turkey
Ho Chi Minh, , Vietnam
Columbia, Missouri, United States
Mlada Boleslav, , Czechia
Aarhus N, , Denmark
København, , Denmark
Melaka, , Malaysia
Santander, , Spain
Hillerød, , Denmark
Strasbourg Cedex, , France
Shenzhen, , China
Zhengzhou, , China
Wuhan, , China
Kawasaki Shi, , Japan
Daegu, , Korea, Republic Of
Taoyuan, , Taiwan
Győr, , Hungary
Beer Sheva, , Israel
Lima, , Peru
Izmir, , Turkey
Silver Spring, Maryland, United States
Kyoto Shi, , Japan
Bradenton, Florida, United States
Porto Alegre, , Brazil
Floridablanca, , Colombia
Kolding, , Denmark
Petah Tikva, , Israel
Hitachi Shi, , Japan
Isehara Shi, , Japan
Kumamoto Shi, , Japan
Takamatsu Shi, , Japan
Urasoe Shi, , Japan
Ureshino Shi, , Japan
Guadalajara, , Mexico
Riyadh, , Saudi Arabia
Shinagawa Ku, , Japan
Cusco, , Peru
Palma De Mallorca, , Spain
Balassagyarmat, , Hungary
Osaka Shi, , Japan
Shatin, , Hong Kong
Tianjin, , China
Yueyang, , China
Bedford Park, , Australia
Port Macquarie, , Australia
Trnava, , Slovakia
Izumo Shi, , Japan
Rzeszów, , Poland
Okayama Shi, , Japan
Atlanta, Georgia, United States
Haikou, , China
Hai Phong, , Vietnam
Huddersfield, , United Kingdom
Potsdam, New York, United States
Pernik, , Bulgaria
Orléans Cedex 2, , France
Warszawa, , Poland
Mumbai, , India
Vijayawada, , India
Kubang Kerian, , Malaysia
Xalapa, , Mexico
Taipei, , Taiwan
Izmir, , Turkey
Hue, , Vietnam
Tucson, Arizona, United States
Montana, , Bulgaria
Angers, , France
Tours, , France
New Lambton Heights, , Australia
Rostock, , Germany
London, , United Kingdom
Saint Paul, Minnesota, United States
Kanazawa Shi, , Japan
Istanbul, , Turkey
Kyjov, , Czechia
Hefei, , China
Köln, , Germany
Nagoya Shi, , Japan
Hangzhou, , China
Belo Horizonte, , Brazil
Medellin, , Colombia
Osaka Shi, , Japan
Changsha, , China
Rosenheim, , Germany
Yantai, , China
Alexandria, , Egypt
Guangzhou, , China
Fukuoka Shi, , Japan
Kagoshima Shi, , Japan
Koshigaya Shi, , Japan
Guadalajara, , Mexico
Gurgaon, , India
Kolin, , Czechia
Rio De Janeiro, , Brazil
Hanyu Shi, , Japan
Ashkelon, , Israel
Plovdiv, , Bulgaria
Belagavi, , India
Kanpur, , India
Kusatsu Shi, , Japan
Tachikawa Shi, , Japan
Caxias Do Sul, , Brazil
Kamakura Shi, , Japan
Trnava, , Slovakia
Bangkok, , Thailand
Pune, , India
Kuala Lumpur, , Malaysia
Pulau Pinang, , Malaysia
Chengdu, , China
Chapel Hill, North Carolina, United States
Omuta Shi, , Japan
Jeddah, , Saudi Arabia
Nantong, , China
Khlong Luang, , Thailand
Diyarbakir, , Turkey
Ourense, , Spain
Lima, , Peru
Calgary, Alberta, Canada
Hyderabad, , India
Thane, , India
Nakagami Gun, , Japan
New Cairo, , Egypt
Yokohama Shi, , Japan
Qingdao, , China
Weifang, , China
Wythenshawe, , United Kingdom
Maebashi Shi, , Japan
Soledad, , Colombia
Sapporo Shi, , Japan
Mar Del Plata, , Argentina
Sao Jose Do Rio Preto, , Brazil
Chiba Shi, , Japan
Créteil, , France
Istanbul, , Turkey
Rosario, , Argentina
Dallas, Texas, United States
Curitiba, , Brazil
Copenhagen ø, , Denmark
Bristol, , United Kingdom
Tlalpan, , Mexico
Seoul, , Korea, Republic Of
Exohi Thessaloniki, , Greece
Munro, , Argentina
Kuantan, , Malaysia
Lima, , Peru
Solna, , Sweden
Gurugram, , India
Natal, , Brazil
Hampshire, , United Kingdom
Montréal, Quebec, Canada
Jeonju, , Korea, Republic Of
Niterói, , Brazil
Beijing, , China
Afula, , Israel
Heraklion, , Greece
Passo Fundo, , Brazil
Ahmedabad, , India
Ribeirão Preto, , Brazil
New York, New York, United States
Bogota Dc, , Colombia
Villavicencio, , Colombia
Torino, , Italy
Sarawak Miri, , Malaysia
El Agustino, , Peru
Piura, , Peru
Västerås, , Sweden
Khon Kaen, , Thailand
Istambul, , Turkey
Prescot, , United Kingdom
Tyne And Wear, , United Kingdom
Sao Paulo, , Brazil
Ciudad Autónoma De Buenos Aires, , Argentina
Praha 5, , Czechia
Nantes Cedex 1, , France
Chennai, , India
Okazaki Shi, , Japan
Petaling Jaya, , Malaysia
Shah Alam, , Malaysia
Salvador, , Brazil
Buenos Aires, , Argentina
Ciudad Autonoma De Buenos Aires, , Argentina
Ciudad Autonoma De Buenos Aire, , Argentina
La Plata, , Argentina
São Paulo, , Brazil
Brampton, Ontario, Canada
San Luis Potosi, , Mexico
Taoyuan City, , Taiwan
Hochiminh City, , Vietnam
Izumisano Shi, , Japan
Hiroshima Shi, , Japan
Gifu Shi, , Japan
Kamogawa Shi, , Japan
Phutthamonthon, , Thailand
South Pasadena, Florida, United States
Caba, , Argentina
Fuyang, , China
Wuhan, , China
Wroclaw, , Poland
łódź, , Poland
Bucharest, , Romania
Westdene, , South Africa
Kuala Terengganu, , Malaysia
Recife, , Brazil
Buenos Aires, , Argentina
Kota Kinabalu, , Malaysia
Aguascalientes, , Mexico
Cairo, , Egypt
Nerima Ku, , Japan
Kumagaya Shi, , Japan
Helsingborg, , Sweden
Huddinge, , Sweden
Johannesburg, Soweto, , South Africa
Cluj Napoca, , Romania
Ciudad De México, , Mexico
Hyderabad, , India
Constanta, , Romania
Iasi, , Romania
Hong Kong, , Hong Kong
Pune, , India
Jaú, , Brazil
İzmit, , Turkey
Tampa, Florida, United States
New Westminster, British Columbia, Canada
łańcut, , Poland
Stockholm, , Sweden
Banphaeo, , Thailand
Jining, , China
Praha, , Czechia
Selangor Darul Ehsan, , Malaysia
Ortahisar, , Turkey
Indaiatuba, , Brazil
São Caetano Do Sul, , Brazil
Ginowan Shi, , Japan
Bucharest, , Romania
Tianjin, , China
Petah Tikva, , Israel
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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