Premarking of Axillary Nodes Before Start of Neoadjuvant Chemotherapy Using Magnetic Approach

Launched by VASTRA GOTALAND REGION · Nov 22, 2022

Keywords

ClinConnect Summary

Breast cancer is one of the commonest types of cancers in females. Treatments include surgery followed by anti-estrogen therapy (tablet form), radiotherapy (radiation) and chemotherapy (intravenous / tablet form). During breast surgery, the surgeon removes the cancer from the breast and lymph nodes (glands) from the armpit.

Historically, all armpit lymph nodes (clearance) were removed irrespective of the stage of armpit disease which can lead to over-treatment and unnecessary long term arm lymphoedema (swelling). However, the modern approach has become more selective. If there are cancer s...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• * A patient meeting the following criteria is eligible for participation in the study:
• • Patients 18 years of age or older
• • Patients with breast cancer planned to undergo preoperative chemotherapy (NACT) with a) planned sentinel lymph node biopsy (SNB) or b) axillary lymph node dissection, in conjunction with the beast surgery after NACT
• Exclusion Criteria:
• • Intolerance / hypersensitivity to iron or dextran compounds or SPIO.
• • Patients who are required to undergo MR to evaluate tumour response
• • Pregnancy or breast feeding
• • Patients with an iron overload disease.
• • Patient deprived of liberty or under guardianship.
• • Inability to understand given information, give informed consent, undergo study procedures
• • MRI (subgroup of patients): Conditions contraindicating MRI including, but not limited to, BMI \> 40 kg/m2, claustrophobia, metallic implants or internal electrical devices (e.g. Pacemaker).