Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis

Launched by ENDEAVOR HEALTH · Nov 15, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at how well different ways of delivering medications can help people with chronic rhinitis, which is a condition that causes symptoms like a runny or stuffy nose. The researchers want to find out if using a high-pressure nasal irrigation method with the medications azelastine and mometasone works better than the standard nasal sprays that use a lower pressure. Over six months, participants will use one of three treatment options: a saline rinse followed by azelastine and mometasone sprays, just mometasone with saline irrigation, or both azelastine and mometasone with saline irrigation.

To join the study, participants must be adults aged 18 or older who have been diagnosed with chronic rhinitis and are willing to try these treatments for six months. However, people with certain other nasal problems, those using specific medications, smokers, and pregnant or breastfeeding women cannot participate. If you decide to participate, you’ll be closely monitored to see how well the different treatments work for you, and you’ll be contributing to important research that could help others with similar conditions in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults 18 years and older seeking treatment for chronic rhinitis and willing to undergo six months of topical therapy.
• • Diagnosis of Chronic Rhinitis.
• Exclusion Criteria:
• • The patient has diagnosis(es) other than chronic rhinitis that can account for his/her symptoms (septal deviation, nasal valve collapse, chronic sinusitis).
• • Use of oral antihistamines or oral steroids, unless patient undergoes a 4 week washout period.
• • Smokers (tobacco, marijuana, vaping, etc.).
• • Known or suspected pregnancy, or lactation.
• • Other medical conditions that the investigator believed would confound the study.
• • Allergy to study drugs.