Precision Prevention Strategy to Increase Uptake and Engagement in Lung Cancer Screening and Smoking Cessation Treatment

Launched by WASHINGTON UNIVERSITY SCHOOL OF MEDICINE · Nov 15, 2022

Keywords

ClinConnect Summary

This study is testing two versions of a personalized risk feedback tool (RiskProfile) to see if it can boost lung cancer screening and smoking-treatment use. Clinicians will be randomly assigned to one of three groups: usual care (standard advice), RiskProfile-Clin (clinical-factor based feedback), or RiskProfile-Gen (clinical plus genetic feedback). The main goal is to find out whether these precision tools help doctors order lung cancer screening and help patients actually complete screening, as well as whether they influence use of smoking-cessation help. The study also looks at how patients and clinicians talk about screening and treatment and how engaged they are in care, with follow-ups for up to about 18 months.

Eligible participants are adults 50–80 years old who currently smoke or have smoked in the past, have at least 20 pack-years, speak English, and are patients of participating primary-care clinicians. People with a lung cancer diagnosis or who already have a screening order are not eligible. The trial plans to enroll around 141 clinicians and about 700 patients (roughly 915 total planned). Participants will have visits with their clinician, receive the assigned RiskProfile information, and be followed over time to see if they get screened and use tobacco treatment. No results are available yet. The study is led by Washington University School of Medicine in St. Louis, and researchers plan to share anonymized genetic data after the trial ends to support future research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• CLINICIANS:
• • - Primary care clinician with active caseload in participating clinics
• PATIENTS:
• • Patient of participating primary care clinician
• • Lung cancer screening naïve
• • Between 50 to 80 years of age, inclusive
• • Current or former smokers
• • Pack years ≥ 20
• • English-speaking
• Exclusion Criteria:
• PATIENTS:
• • Lung cancer diagnosis
• • Current order placed for lung cancer screening