Effect of Early Non-invasive Phrenic Nerve Stimulation on Weaning in Mechanically Ventilated Patients

Launched by BING SUN · Nov 18, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called non-invasive phrenic nerve stimulation (PNS) for patients who are on mechanical ventilation, which is a machine helping them breathe. The goal is to see if starting this treatment early can help patients breathe on their own sooner, improve their breathing muscle strength, and prevent muscle wasting from not using those muscles. This is important because it can help patients recover faster and spend less time on the ventilator.

To participate in this study, patients need to be between 18 and 80 years old and have been on mechanical ventilation for no more than 48 hours, with a plan to be on it for at least 72 hours. They should not have certain health issues, such as serious lung problems or specific heart conditions, and they must be willing to sign a consent form. If they join, participants can expect to receive the PNS treatment while being closely monitored by the research team to track their progress. This study is currently looking for volunteers, so interested patients or their families can ask more questions to learn about taking part.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18years and ≤80years;
• • MV time ≤48h;
• • MV duration is expected to be ≥72h;
• • The sternocleidomastoid region and pectoralis major region were completely exposed.
• • Patients or family members are willing to sign informed consent and participate in the study.
• Exclusion Criteria:
• • There are contraindications to PNS in vitro (Pneumothorax, active tuberculosis, pleural adhesions, installation of pacemakers and defibrillators, etc.);
• • Neuromuscular disease (myasthenia gravis, etc.) or known anatomical abnormalities of the diaphragm;
• • ECMO status;
• • Hemodynamic instability;
• • Uncorrected arrhythmias;
• • Be pregnant;
• • Clinical end-stage and palliative care patients.