Alteration of Symbiosis Intestinal Microbiota on Patients With Anorexia Nervosa

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Nov 21, 2022

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how changes in the gut microbiome (the community of bacteria and other microorganisms in our intestines) might relate to symptoms experienced by individuals with Anorexia Nervosa, such as anxiety and depression. Researchers want to see if issues like poor nutrition, gut health, and inflammation are connected to the severity of these symptoms in patients. They are currently looking for participants, including those diagnosed with Anorexia Nervosa and healthy volunteers, to help them explore these relationships.

To be eligible for the study, participants must be at least 18 years old. For patients, they should have a very low body mass index (BMI) and be hospitalized for nutritional support. Healthy volunteers should have a normal BMI. Participants will be asked to sign a consent form and may undergo assessments related to their gut health and mental well-being. This study aims to improve our understanding of Anorexia Nervosa and could lead to better treatments in the future. If you're considering participating, it's important to know that those with certain health conditions or recent changes in weight may not qualify, so discussing your situation with the study team is crucial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• For patients:
• • Patients aged ≥18 years;
• • Anorexia according to DSM-5 and CIDI (Composite International Diagnostic Interview);
• • Body mass index (BMI) (P/T2) \< 15;
• • Hospitalization for nutrition rehabilitation;
• • Covered by a health insurance;
• • Informed consent form signed.
• For Healthy Volunteers:
• • Aged ≥18 years;
• • 18.5 \< BMI (P/T2) \< 25;
• • Covered by a health insurance;
• • Informed consent form signed.
• Exclusion Criteria:
• For patients:
• • Patients no-responding all criteria of DSM-5 or CIDI scores;
• • Taken of antibiotic treatment 2 months / or laxativ 3 weeks before hospitalization;
• • Somatic comorbidity should perturb intestinal microbiota (Crohn's disease, diabetes and all other chronic inflammatory diseases);
• • Patients under guardianship;
• • Patients covered by french AME scheme.
• For Healthy Volunteers:
• • Any disease should perturb intestinal microbiota;
• • Recent ponderal variation;
• • Taken of antibiotic treatment 2 months or laxativ 3 weeks before hospitalization;
• • Under guardianship;
• • Covered by french AME scheme.