Semantic Networks in Alcohol Use Disorder Patients: Exploratory Study

Launched by INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, FRANCE · Dec 1, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating how people with Alcohol Use Disorder (AUD) think about and associate different words, particularly those related to alcohol. Researchers believe that individuals with AUD may have a different way of organizing these associations in their memory compared to healthy individuals. The goal is to see if these differences affect their ability to stay away from alcohol after they stop drinking and how it relates to their decision-making and self-control skills.

To participate in this study, individuals with severe AUD must be French-speaking, right-handed, and have been abstinent from alcohol for 15 to 30 days prior to joining. Healthy participants also need to meet similar language and handedness criteria. Everyone will undergo two assessments that involve word association tasks and tests that measure their thinking skills, both at the beginning of the study and three months later. The study is currently looking for volunteers, and those who join can contribute to a better understanding of how memory and thought processes relate to alcohol use and recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • For alcohol use disorder patients
• • Severe alcohol use disorder
• • French as mother tongue
• • Right-hander
• • Patient abstinent from alcohol since 15 to 30 days at the inclusion
• • Patient free from benzodiazepine since at least 48hours at the inclusion
• • Patient who gave his informed written consent
• • Currently in outpatient or inpatient care
• • For healthy controls
• • French as mother tongue
• • Right-hander
• • Participant who gave his informed written consent
• Exclusion Criteria:
• • For alcohol use disorder patients
• • Patient under guardianship or under justice safeguard measures
• • Patient under measure of therapeutic injunction
• • Pregnancy or breastfeeding declared
• • Meeting Diagnostic and Statistical Manual 5 (DSM) criteria for substance use disorder other than Tobacco
• • Meeting DSM-5 criteria for non substance use disorder
• • Patient presenting severe or progressive disease that interfere with experimental tasks, such as neurological diseases (TBI, epilepsy, stoke) , hepatic diseases, cancer, HIV, Hepatitis C Virus (HCV), and unstable psychiatric comorbidities.
• • For healthy controls
• • Participant under guardianship or under justice safeguard measures
• • Participant under measure of therapeutic injunction
• • Pregnancy or breastfeeding declared
• • Meeting DSM-5 criteria for alcohol use disorder
• • Meeting DSM-5 criteria for substance use disorder other than Tobacco
• • Meeting DSM-5 criteria for non substance use disorder
• • Currently under benzodiazepine
• • Participant presenting severe or progressive disease that interfere with experimental tasks, such as neurological diseases (TBI, epilepsy, stoke) , hepatic diseases, cancer, HIV, HCV, and unstable psychiatric comorbidities.

Trial Officials