Neutrophil-to-lymphocyte and Platelet-to-lymphocyte Ratio in Predicting the Incidence of Nausea and Vomiting

Launched by QIANFOSHAN HOSPITAL · Dec 2, 2022

Keywords

ClinConnect Summary

Hemophilia arthropathy is a debilitating complication of hemophilia that occurs primarily in severe forms with recurrent spontaneous intra-articular hemorrhage, with the knee being the most commonly affected joint. Currently, total knee arthroplasty is the standard treatment for end-stage hemophilic arthropathy. Due to the special disease of hemophilia, general anesthesia is often chosen as the preferred anesthesia method, and the risk of bleeding is lower than that of neuraxial anesthesia. However, 20 to 30 percent of surgical patients suffer from post-operative nausea and vomiting after g...

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • 1. The patients with hemophilia A undergoing unilateral total knee arthroplasty.
• • 2. The age of the patients ranged from 18 to 70 years.
• • 3. American Society of Anesthesiologists is graded as I\~III
• • 4. No history of mental illness
• • 5. No history of antiemetic and anticholinergic drugs.
• • 6. No history of serious gastrointestinal diseases.
• Exclusion Criteria:
• • 1. Patients who have received long-term steroid treatment
• • 2. Patients who need more than 2.5 mg neostigmine to reverse muscle relaxants
• • 3. Patients with previous malignant tumor, malabsorption, morbid obesity, hypogonadism, thyroid and parathyroid diseases and autoimmune diseases.

Trial Officials