A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
Launched by NOVO NORDISK A/S · Nov 23, 2022
Trial Information
Current as of September 29, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a new treatment called ziltivekimab for people with heart failure who also have inflammation. Heart failure means the heart isn't pumping blood as well as it should, and inflammation can make this condition worse. In the trial, participants will receive either ziltivekimab or a placebo (a dummy treatment) through injections once a month. The study will last up to four years, and participants will need to visit the clinic up to 20 times. Additionally, they'll use a study app on their phone to track their injections and answer some questions about their health.
To be eligible for this study, participants should be between the ages of 65 and 74 and have certain heart-related conditions, including specific blood test results indicating heart failure. They should not have had major recent heart issues or surgeries. This trial is currently recruiting, and it’s important for anyone interested to discuss with their doctor to see if they qualify. The study aims to determine if ziltivekimab can help improve heart failure symptoms, potentially offering new hope for patients dealing with this challenging condition.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Serum high-sensitivity C-reactive protein (hs-CRP) greater than equal to 2 milligrams per liter (mg/L) at screening (visit 1) Disease specific - cardiovascular
- * At least one of the following:
- • 1. N-terminal-pro-brain natriuretic peptide (NT-proBNP) greater than equal to 300 picograms per milliliter (pg/mL) at screening (Visit 1) for patients without ongoing atrial fibrillation/flutter. If ongoing atrial fibrillation/flutter at screening (visit 1), NTproBNP must be greater than equal to 600 pg/mL. Note that the screening electrocardiogram (ECG) must be obtained the same day as sampling for NT-proBNP.
- • 2. Hospitalisation or urgent/unplanned visit with a primary diagnosis of decompensated heart failure which required intravenous loop diuretic treatment, within the last 9 months prior to screening (visit 1) in combination with NT-proBNP greater than equal to 200 pg/mL at screening (Visit 1) for patients without ongoing atrial fibrillation/flutter. If ongoing atrial fibrillation/flutter at screening (visit 1), NT-proBNP must be greater than equal to 600 pg/mL.
- • Diagnosis of heart failure (New York Heart Association \[classification\] \[NYHA\] Class II-IV).
- • Left ventricular ejection fraction (LVEF) greater than 40 percentage (%) documented by echocardiography within 12 months prior to or at screening (visit 1). The LVEF must be documented in medical records and the most recent measurement must be used to determine eligibility with no interim event signalling potential deterioration in ejection fraction (e.g., myocardial infarction \[MI\] or heart failure \[HF\] hospitalisation).
- * Structural heart disease and/or functional heart disease documented by echocardiography within 12 months prior to or at screening (visit 1) showing at least one of the following:
- • Left atrial (LA) volume index greater than 34 milliliter per meter square (mL/m\^2).
- • LA diameter greater than equal to 3.8 centimeter (cm).
- • LA length greater than equal to 5.0 cm.
- • LA area greater than equal to 20 cm square.
- • LA volume greater than equal to 55 milliters (mL).
- • Intraventricular septal thickness greater than equal to 1.1 cm.
- • Posterior wall thickness greater than equal to 1.1 cm.
- • Left ventricular (LV) mass index greater than equal to 115 grams per meter square (g⁄m\^2 ) in men or greater than equal to 95 g⁄m\^2 in women.
- • E/e' (mean septal and lateral) greater than equal to 10.
- • e' (mean septal and lateral) less than 9 centimeter per second (cm/s).
- • No heart failure hospitalisations or urgent heart failure visits between screening (visit 1) and randomisation (visit 2).
- Exclusion Criteria:
- • Medical conditions - cardiovascular
- • Myocardial infarction, stroke, unstable angina pectoris, transient ischaemic attack, or heart failure hospitalisation, within 30 days prior to screening (visit 1).
- • Systolic blood pressure greater than equal to 180 millimeters of mercury (mmHg) at screening (visit 1). If the systolic blood pressure is 160-179 mmHg, the patient should be receiving greater than equal to 3 antihypertensive drugs. (Note: Potential participants may be retested for this criterion within the visit window and without rescreening, at the discretion of the investigator).
- • Heart rate above 110 or below 40 beats per minute as evaluated on the electrocardiogram (ECG) performed at screening (visit 1) (Note: Potential participants may be retested for this criterion within the visit window and without rescreening, at the discretion of the investigator).
- • Planned coronary, carotid or peripheral artery revascularisation known during the screening period (visit 1). (Note: Planned coronary angiogram is not exclusionary).
- • Planned cardiac device or atrial flutter/atrial fibrillation ablation procedure known during the screening period (visit 1).
- • Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit 2) or any major surgical procedure planned at the time of randomisation (visit 2).
- • Heart failure due to infiltrative cardiomyopathy (e.g., sarcoid, amyloid), arrhythmogenic right ventricular cardiomyopathy, Takutsubo cardiomyopathy, genetic hypertrophic cardiomyopathy or obstructive cardiomyopathy, active myocarditis, constrictive pericarditis, cardiac tamponade, uncorrected more than moderate primary valve disease.
- • Primary pulmonary hypertension, chronic pulmonary embolism, severe pulmonary disease including COPD.
- • Any other condition judged by the investigator that could account for heart failure symptoms and signs (e.g., anaemia, hypothyroidism).
- • Medical conditions - infections/immunosuppression
- • - Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.
About Novo Nordisk A/S
Novo Nordisk A/S is a global healthcare company headquartered in Denmark, specializing in the research, development, manufacturing, and marketing of innovative pharmaceuticals, particularly in the fields of diabetes care, obesity treatment, and hormone replacement therapies. With a strong commitment to improving patient outcomes, Novo Nordisk invests significantly in clinical trials to advance scientific knowledge and develop effective therapies. The company is dedicated to sustainability and ethical practices, striving to deliver high-quality healthcare solutions while addressing the evolving needs of patients worldwide. Through collaboration and innovation, Novo Nordisk aims to lead the way in transforming diabetes and other chronic diseases into manageable conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
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Shanghai, Shanghai, China
Flint, Michigan, United States
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Novara, Italy
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Beijing, China
Guangzhou, Guangdong, China
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Tijuana, Baja California, Mexico
Kaiserslautern, Germany
Kuala Lumpur, Malaysia
Amarillo, Texas, United States
Douglas, Queensland, Australia
Chongqing, Chongqing, China
Sevilla, Spain
Osijek, Croatia
Kanagawa, Japan
Osaka, Japan
Tottori, Japan
Tianjin, China
Surrey, British Columbia, Canada
Munster, Indiana, United States
Elizabethtown, Kentucky, United States
Camp Hill, Pennsylvania, United States
Amarillo, Texas, United States
Szeged, Hungary
Zhenjiang, Jiangsu, China
Norfolk, Virginia, United States
Covina, California, United States
Brescia, Italy
Foggia, Italy
Naples, Florida, United States
Athens, Greece
Exeter, United Kingdom
Lom, Bulgaria
Maribor, Slovenia
New Delhi, India
Honolulu, Hawaii, United States
Haifa, Israel
Incheon, Korea, Republic Of
Lørenskog, Norway
Fairhope, Alabama, United States
Falls Church, Virginia, United States
Concord, New South Wales, Australia
Bedford Park, South Australia, Australia
Newmarket, Ontario, Canada
Würzburg, Germany
Komárom, Hungary
Gdynia, Poland
Lodz, Poland
Roanoke, Virginia, United States
Jaipur, Rajasthan, India
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Santa Fe, Argentina
Sevilla, Spain
Jodhpur, Rajasthan, India
Braunau, Austria
Graz, Austria
Kochi, Kerala, India
Cona (Ferrara), Italy
Okayama Shi, Okayama, Japan
Jyväskylä, Finland
Chaidari, Athens, Greece
Tianjin, China
Worcester, Western Cape, South Africa
Békéscsaba, Hungary
Haverhill, Massachusetts, United States
Grand Rapids, Michigan, United States
Bridgewater, New Jersey, United States
Knoxville, Tennessee, United States
San Nicolás, Argentina
Vitória, Espirito Santo, Brazil
Waterloo, Ontario, Canada
Brossard, Quebec, Canada
Athens, Greece
Trieste, Italy
Gwangju, Korea, Republic Of
Grodzisk Mazowiecki, Poland
Krakow, Poland
Ruda Slaska, Poland
Afyon, Turkey
Dorest, United Kingdom
Stockton On Tees, United Kingdom
Belgrade, Serbia
Edmonton, Alberta, Canada
Chongqing, Chongqing, China
Buenos Aires, Argentina
Riga, Latvia
Norfolk, Virginia, United States
Changzhou, China
Göttingen, Germany
Craigavon, United Kingdom
Adelaide, South Australia, Australia
Oshawa, Ontario, Canada
Halifax, Nova Scotia, Canada
Veliko Tarnovo, Bulgaria
Orange, California, United States
Bengaluru, Karnataka, India
Greensboro, North Carolina, United States
Monterrey, Nuevo Leon, Mexico
Warszawa, Poland
Changsha, Hunan, China
Cheras, Kuala Lumpur, Malaysia
Sungai Buloh, Selangor, Malaysia
Pleven, Bulgaria
Wroclaw, Dolnoslaskie, Poland
Norfolk, Virginia, United States
Pisa, Pi, Italy
Kosice, Slovakia
Towson, Maryland, United States
Hat Yai, Songkla, Thailand
Praha 2, Czechia
Himeji Shi, Hyogo, Japan
Lancaster, Pennsylvania, United States
Sherman, Texas, United States
Caba, Buenos Aires, Argentina
Granadero Baigorria, Santa Fe, Argentina
Santa Fe, Argentina
Porto Alegre, Rio Grande Do Sul, Brazil
Belo Horizonte/Mg, Brazil
Goiânia/Go, Brazil
Porto Alegre/Rs, Brazil
Recife/Pe, Brazil
Ribeirão Preto/Sp, Brazil
Rio De Janeiro, Brazil
São Paulo/Sp, Brazil
Veliko Tarnovo, Bulgaria
Cambridge, Ontario, Canada
Guelph, Ontario, Canada
Bremen, Germany
Dortmund, Germany
Göttingen, Germany
Haßloch, Germany
Mannheim, Germany
Rio Patras, Greece
Thessaloniki, Greece
Vadodara, Gujarat, India
Cork, Ireland
Zrifin, Israel
Torino, Italy
Riga, Latvia
Emmen, Netherlands
Enschede, Netherlands
Guilhufe Penafiel, Portugal
Lisbon, Portugal
Bucuresti, Romania
Brezno, Banskobystricky Kraj, Slovakia
Svidnik, Presovsky Kraj, Slovakia
Trnava, Slovakia
Shenzhen, Guangdong, China
Wuhan, Hubei, China
Split, Croatia
Liberec, Czechia
Bangalore, Karnataka, India
Palakkad, India
Morioka Shi, Iwate, Japan
Włocławek, Poland
Bucuresti, Buzau, Romania
Baia Mare, Romania
Braila, Romania
Bucharest, Romania
Bucuresti, Romania
Craiova, Romania
Craiova, Romania
Iasi, Romania
Pitesti, Romania
Targu Mures, Romania
Timisoara, Romania
Mossel Bay, Western Cape, South Africa
Trois Rivieres, Quebec, Canada
Elkhart, Indiana, United States
Madison, Wisconsin, United States
Panagyurishte, Bulgaria
Sandanski, Bulgaria
Winnipeg, Manitoba, Canada
Manizales, Caldas, Colombia
Plzen Bory, Czechia
Uherske Hradiste, Czechia
Copenhagen, Denmark
Jena, Germany
Papenburg, Germany
Heraklion, Crete, Greece
Pylea, Thessaloniki, Greece
Orosháza, Hungary
Pécs, Hungary
Benevento, Italy
Casale Monferrato, Italy
Rivoli, Italy
Roma, Italy
Aguascalientes, Ags, Mexico
Santiago De Querétaro, Qro., Querétaro, Mexico
Xalapa, Veracruz, Mexico
Belchatow, Poland
Chrzanów, Poland
Dąbrowa Górnicza, Poland
Katowice, Poland
Kraków, Poland
Przemysl, Poland
Bratislava, Slovakia
Badalona, Barcelona, Spain
Frederiksberg, Denmark
Tampere, Finland
Piraeus, Greece
Chichester, West Sussex, United Kingdom
Hyderabad, Telengana, India
Nis, Serbia
Sremska Kamenica, Serbia
Minneapolis, Minnesota, United States
Winchester, Ontario, Canada
Sherbrooke, Quebec, Canada
Floridablanca, Santander, Colombia
Medellin, Colombia
Marousi, Greece
Aligarh, India
Santiago De Querétaro, Querétaro, Mexico
Enschede, Netherlands
Bialystok, Poland
Timișoara, Romania
Pretoria, Gauteng, South Africa
Bucaramanga Piedecuesta, Valle Del Menzuli Santander, Santander, Colombia
Atlanta, Georgia, United States
Bronx, New York, United States
Jackson, Tennessee, United States
New Westminster, British Columbia, Canada
North Vancouver, British Columbia, Canada
Surrey, British Columbia, Canada
Vancouver, British Columbia, Canada
Montréal, Quebec, Canada
Trois Rivières, Quebec, Canada
Gurugram, Haryana, India
Dehradun, Uttarakhand, India
Jodhpur, India
Tirgu Mures, Targu Mures, Romania
Las Palmas De Gran Canaria, Spain
Timisoara, Romania
Uwajima Shi, Ehime, Japan
North Miami Beach, Florida, United States
Indianapolis, Indiana, United States
Lebanon, Indiana, United States
Maplewood, Minnesota, United States
Hassloch, Germany
Lucknow, India
Cracow, Poland
Rio De Janeiro, Rj, Brazil
Kuopio, Finland
Wenzhou, Zhejiang, China
Guntur, Andhra Pradesh, India
Kota Bharu, Kelantan, Malaysia
Dublin, Leinster, Ireland
New Delhi, Delhi, India
Balatonfüred, Hungary
Pathumthani, Thailand
Klong Luang, Pathumthani, Pathumthani, Thailand
Komárom, Komárom Esztergom, Hungary
Warszawa, Mazowieckie, Poland
Cidade Nova Votuporanga, São Paulo, Brazil
Klaipeda, Lithuania
Siauliai, Lithuania
Orange, California, United States
Littleton, Colorado, United States
Naples, Florida, United States
Downers Grove, Illinois, United States
Peoria, Illinois, United States
Hammond, Indiana, United States
Albany, New York, United States
Raleigh, North Carolina, United States
Canton, Ohio, United States
Sioux Falls, South Dakota, United States
Milwaukee, Wisconsin, United States
Vienna, Austria
Marília/Sp, Brazil
New Westminster, British Columbia, Canada
Victoria, British Columbia, Canada
Cali, Colombia
Puducherry, India
Kyoto, Japan
Sztum, Poland
Zgierz, Poland
Bangkok, Thailand
Tooting, London, United Kingdom
Hellerup, Region Hovedstaden, Denmark
Svendborg, Region South, Denmark
Ypsilanti, Michigan, United States
Siena, Si, Italy
Afyon, Turkey
Stamford, Connecticut, United States
Bialystok, Podlaskie, Poland
Zabrze, Slaskie, Poland
Lodz, Lodzkie, Poland
Linden, New Jersey, United States
Manassas, Virginia, United States
Milwaukee, Wisconsin, United States
Oshawa, Ontario, Canada
St. Jean Sur Richelieu, Quebec, Canada
Saskatoon, Saskatchewan, Canada
Xi'an, Shaanxi, China
Anhui/Huainan, China
Shanghai, China
Tianjin, China
Athens, Attiki, Greece
Karnataka, India
Casale Monferrato, Al, Italy
Bergamo, Bg, Italy
Benevento, Bn, Italy
Brescia, Bs, Italy
Caserta, Ce, Italy
Catanzaro, Cz, Italy
Cona (Ferrara), Fe, Italy
Genova, Ge, Italy
Perugia, Pg, Italy
Pisa, Pi, Italy
Roma, Rm, Italy
Rivoli, To, Italy
Torino, To, Italy
Verona, Vr, Italy
Ishikawa, Japan
Tijuana, Baja California, Mexico
Włocławek, Kujawsko Pomorskie, Poland
Belchatow, Lodzkie, Poland
Chrzanów, Małopolskie, Poland
Cracow, Małopolskie, Poland
Katowice, Silesian Voivodeship, Poland
Dąbrowa Górnicza, śląskie, Poland
Tychy, śląskie, Poland
Basildon, United Kingdom
Craigavon, United Kingdom
North Shields, United Kingdom
Ibaraki, Japan
Tijuana, Baja California, Mexico
Cakovec, Croatia
Waterloo, Ontario, Canada
Brno, Czechia
Baja, Bács Kiskun, Hungary
Békéscsaba, Békés Megye, Hungary
Zalaegerszeg, Zala Megye, Hungary
Sudbury, Ontario, Canada
Haikou, Hainan, China
Lishui, Zhejiang, China
Ha Erbin, China
Pécs, Baranya Megye, Hungary
Orosháza, Békés Megye, Hungary
Szeged, Csongrád Csanád, Hungary
Kaposvár, Somogy Megye, Hungary
Yamaguchi, Japan
San Nicolas De Los Garza, Nl, Mexico
Kota Samarahan, Sarawak, Malaysia
Ruda Slaska, Silesian Voivodeship, Poland
Lancaster, Pennsylvania, United States
El Paso, Texas, United States
Herlev, Region Hovedstaden, Denmark
Mahon, Cork, Ireland
Cheongju, Korea, Republic Of
Torun, Kuyavian Pomeranian Voivodeship, Poland
Bialystok, Podlaskie Voivodeship, Poland
Zgierz, łódź Voivodeship, Poland
Homburg, Germany
Fukuoka, Japan
Miyagi, Japan
Basildon, Essex, United Kingdom
Airdrie, Lanarkshire, United Kingdom
Lanham, Maryland, United States
Montreal, Quebec, Canada
Split, Dalmatia, Croatia
Zagreb, Grad Zagreb, Croatia
Krapinske Toplice, Krapinsko Zagorska County, Croatia
Bengaluru, India
Kanagawa, Japan
Okayama, Japan
Toyama, Japan
Hospitalet De Llobregat, Barcelona, Spain
Kaohsiung City, Taiwan
East Kilbride, South Lanarkshire, United Kingdom
São Paulo/Sp, Brazil
Soledad, Barranquilla, Colombia
Yokohama, Kanagawa, Japan
Durban, Kwwazulu Natal, South Africa
L'hospitalet De Llobregat, Barcelona, Spain
Uherské Hradiště, Czechia
Craiova, Romania
Buzau, Romania
Kew Gardens, New York, United States
Belo Horizonte, Minas Gerais, Brazil
Medellin, Antioquia, Colombia
Barranquilla, Atlántico, Colombia
Nagasaki, Japan
Pascani, Romania
Gyula, Hungary
łódź, Poland
Winter Haven, Florida, United States
Aracaju, Brazil
Suzhou, Jiangsu, China
Spokane, Washington, United States
Plzen Lochotín, Czechia
Bucuresti, Romania
Yokohama Shi, Kanagawa, Japan
Guadalajara, Jalisco, Mexico
Alcabideche, Portugal
Frankston, Victoria, Australia
Hyogo, Japan
Mie, Japan
Jodhpur, Rajasthan, India
Imabari Shi, Ehime, Japan
Kagawa, Japan
Kanagawa, Japan
Kishiwada Shi, Osaka, Japan
Saga, Japan
Wyomissing, Pennsylvania, United States
Chesterfield, Virginia, United States
Jingan/Shanghai, China
Medellin, Antioquia, Colombia
Bogalusa, Louisiana, United States
Gifu, Japan
Hokkaido, Japan
Yamaguchi, Japan
Rosedale, New York, United States
Cluj Napoca, Cluj, Romania
Bergamo, Lombardia, Italy
New Delhi, Delhi, India
Uwajima Shi, Ehime, Ehime, Uwajima Shi, Japan
La Jolla, California, United States
Miami, Florida, United States
Naperville, Illinois, United States
Elmer, New Jersey, United States
Mullica Hill, New Jersey, United States
Oklahoma City, Oklahoma, United States
Allen, Texas, United States
Brisbane, Australia
Nanning, China
Okayama, Japan
Shizuoka, Japan
Stockton, California, United States
Seattle, Washington, United States
Surrey, British Columbia, Canada
Oslo, Norway
Duncanville, Texas, United States
Dorset, United Kingdom
Hus, Finland
Bengaluru, Karnataka, India
Hyderabad, Telangana, India
Zagreb, Grad Zagreb, Croatia
Vijaywada, Andhra Pradesh, India
Kuala Lumpur, Malaysia
Cape Town, Western Cape, South Africa
Jacksonville, Florida, United States
Winchester, Virginia, United States
Saint Stefan, Austria
Wien, Austria
Elsterwerda, Germany
Chandigarh, Punjab, India
Dublin, Leinster, Ireland
Warszawa, Mazowieckie, Poland
Klong Luang, Pathumthani, Pathumthani, Thailand
Beverly Hills, California, United States
Wellington, Florida, United States
Overland Park, Kansas, United States
Baltimore, Maryland, United States
Saint Louis, Missouri, United States
Duncanville, Texas, United States
Mckinney, Texas, United States
San Antonio, Texas, United States
Salem, Virginia, United States
Caba, Buenos Aires, Argentina
Mar Del Plata, Argentina
San Nicolás, Argentina
Adelaide, South Australia, Australia
Perth, Western Australia, Australia
Vitória, Espirito Santo, Brazil
Rio De Janeiro, Rj, Brazil
Campinas, Sao Paulo, Brazil
Campinas, Sao Paulo, Brazil
Campinas, Sao Paulo, Brazil
São José Do Rio Preto, Sao Paulo, Brazil
Kozloduy, Bulgaria
Panagyurishte, Bulgaria
Pleven, Bulgaria
Plovdiv, Bulgaria
Plovdiv, Bulgaria
Sofia, Bulgaria
Sofia, Bulgaria
Stara Zagora, Bulgaria
Waterloo, Ontario, Canada
Brossard, Quebec, Canada
Terrebonne, Quebec, Canada
Soledad, Barranquilla, Colombia
Bucaramanga Piedecuesta, Valle Del Menzuli Santander, Santander, Colombia
Barranquilla, Colombia
Barranquilla, Colombia
Svendborg, Region South, Denmark
Frankfurt, Germany
Ahmedabad, Gujarat, India
Jaipur, Rajasthan, India
Jodhpur, Rajasthan, India
Hyderabad, Telangana, India
Dehradun, Uttarakhand, India
Osaka, Japan
Takamatsu Shi, Kagawa, Japan
Monterrey, Nuevo León, Mexico
San Luis Potosí, San Luis Potosi, Mexico
Belchatow, Lodzkie, Poland
Bialystok, Podlaskie, Poland
Zabrze, Slaskie, Poland
Katowice, śląskie, Poland
Pretoria, Gauteng, South Africa
Cape Town, Western Cape, South Africa
Mossel Bay, Western Cape, South Africa
Castilleja Dela Cuesta Sevilla, Spain
Las Palmas De Gran Canaria, Spain
Bangkok, Thailand
Kayseri, Turkey
Mersin, Turkey
Rijeka, Croatia
Athens, Greece
Aligarh, India
Changsha, Hunan, China
Rapid City, South Dakota, United States
Lisboa, Portugal
Geelong, Victoria, Australia
Changzhou, Jiangsu, China
Zagreb, Grad Zagreb, Croatia
Hyderabad, Telengana, India
Iasi, Romania
Johannesburg, Gauteng, South Africa
Nagpur, Maharashtra, India
Manchester, United Kingdom
Sungai Buloh, Selangor, Malaysia
Sofia, Bulgaria
Cali, Colombia
Pascani, Romania
Gurugram, Haryana, India
Wroclaw, Dolnoslaskie, Poland
Oradea, Romania
Kragujevac, Serbia
Sofia, Bulgaria
Larissa, Greece
Catanzaro, Cz, Italy
Guarda, Portugal
Bucuresti, Romania
Galati, Romania
New York, New York, United States
Munster, Indiana, United States
Bogalusa, Louisiana, United States
Camp Hill, Pennsylvania, United States
North York, Ontario, Canada
Athens, Greece
Athens, Greece
Chios, Greece
Szeged, Csongrád Csanád, Hungary
Zalaegerszeg, Zala Megye, Hungary
Budapest, Hungary
Pécs, Hungary
Surat, Gujarat, India
Nagpur, Maharashtra, India
Krakow, Poland
Taoyuan City, Taiwan
Torrance, California, United States
Crystal River, Florida, United States
Fort Lauderdale, Florida, United States
Johns Creek, Georgia, United States
Caba, Argentina
Garran, Australian Capital Territory, Australia
Genk, Belgium
Uberlândia, Minas Gerais, Brazil
Plovdiv, Bulgaria
Barranquilla, Atlántico, Colombia
Medellin, Colombia
Krapinske Toplice, Krapinsko Zagorska County, Croatia
Rijeka, Croatia
Policka, Czechia
Slany, Czechia
Tabor, Czechia
Aarhus N, Denmark
Turku, Finland
La Tronche, France
Aachen, Germany
Dresden, Germany
Wermsdorf, Germany
Athens, Greece
Baja, Bács Kiskun, Hungary
Vijayawada, Andhra Pradesh, India
Nagpur, Maharashtra, India
New Dehli, New Delhi, India
Hyderabad, Telangana, India
Dublin, Ireland
Jerusalem, Israel
Tel Aviv, Israel
Tel Hashomer, Israel
Bunkyo Ku, Tokyo, Japan
Tokyo, Japan
Riga, Latvia
Kota Samarahan, Sarawak, Malaysia
Ciudad De Mexico, México, D.F., Mexico
Culiacán, Sinaloa, Mexico
Oslo, Norway
Belgrade, Serbia
Belgrade, Serbia
Bloemfontein, Free State, South Africa
Cape Town, Western Cape, South Africa
Bangkok, Thailand
Eskisehir, Turkey
Izmir, Turkey
Izmir, Turkey
Loma Linda, California, United States
Roskilde, Denmark
Paris, France
Constanta, Romania
George, Eastern Cape, South Africa
Bridgewater, New Jersey, United States
New York, New York, United States
Houston, Texas, United States
Caba, Argentina
Mar Del Plata, Argentina
Kortrijk, Belgium
Cidade Nova Votuporanga, São Paulo, Brazil
Pleven, Bulgaria
Sofia, Bulgaria
Newmarket, Ontario, Canada
Lanzhou, Gansu, China
Jingan/Shanghai, China
Liberec, Czechia
Homburg, Germany
Jena, Germany
Mannheim, Germany
Athens, Greece
Pylea, Thessaloniki, Greece
Békéscsaba, Békés Megye, Hungary
Komárom, Komárom Esztergom, Hungary
Baja, Hungary
New Delhi, Delhi, India
New Delhi, Delhi, India
Bangalore, Karnataka, India
Bengaluru, Karnataka, India
Pune, Maharashtra, India
Palakkad, India
Cona (Ferrara), Fe, Italy
Trieste, Italy
Uwajima Shi, Ehime, Ehime, Uwajima Shi, Japan
Fukuoka Shi, Fukuoka, Japan
Hamamatsu Shi, Shizuoka, Japan
Ibaraki, Japan
Morioka Shi, Iwate, Japan
Osaka, Japan
Yokohama Shi, Kanagawa, Japan
Jelgava, Latvia
Riga, Latvia
Kaunas, Lithuania
Kaunas, Lithuania
Vilnius, Lithuania
Monterrey, Nuevo Leon, Mexico
Wroclaw, Dolnoslaskie, Poland
Wroclaw, Dolnoslaskie, Poland
Włocławek, Kujawsko Pomorskie, Poland
Lodz, Lodzkie, Poland
Ruda Slaska, Silesian Voivodeship, Poland
Gdynia, Poland
Grodzisk Mazowiecki, Poland
Krakow, Poland
Guilhufe Penafiel, Portugal
Lisbon, Portugal
Setubal, Portugal
Baia Mare, Romania
Braila, Romania
Brasov, Romania
Bucharest, Romania
Bucuresti, Romania
Bucuresti, Romania
Bucuresti, Romania
Bucuresti, Romania
Bucuresti, Romania
Buzau, Romania
Craiova, Romania
Iasi, Romania
Pitesti, Romania
Belgrade, Serbia
Nis, Serbia
Sremska Kamenica, Serbia
Ankara, Turkey
Ankara, Turkey
Istanbul, Turkey
Stockton On Tees, United Kingdom
Vancouver, British Columbia, Canada
München, Germany
Würzburg, Germany
Pisa, Pi, Italy
Okayama Shi, Okayama, Japan
Alexander City, Alabama, United States
Fairhope, Alabama, United States
Huntsville, Alabama, United States
Little Rock, Arkansas, United States
La Jolla, California, United States
La Mesa, California, United States
Los Angeles, California, United States
Palo Alto, California, United States
Van Nuys, California, United States
Littleton, Colorado, United States
Hollywood, Florida, United States
Jacksonville, Florida, United States
Miami, Florida, United States
North Miami Beach, Florida, United States
Saint Augustine, Florida, United States
Atlanta, Georgia, United States
Macon, Georgia, United States
Honolulu, Hawaii, United States
Naperville, Illinois, United States
Peoria, Illinois, United States
Peoria, Illinois, United States
Elkhart, Indiana, United States
Hammond, Indiana, United States
Indianapolis, Indiana, United States
Elizabethtown, Kentucky, United States
Baltimore, Maryland, United States
Lanham, Maryland, United States
Ann Arbor, Michigan, United States
Detroit, Michigan, United States
Detroit, Michigan, United States
Minneapolis, Minnesota, United States
Tupelo, Mississippi, United States
Omaha, Nebraska, United States
Elmer, New Jersey, United States
Livingston, New Jersey, United States
Mullica Hill, New Jersey, United States
Newark, New Jersey, United States
Ridgewood, New Jersey, United States
Albany, New York, United States
Buffalo, New York, United States
Kew Gardens, New York, United States
New York, New York, United States
New York, New York, United States
Chapel Hill, North Carolina, United States
Greensboro, North Carolina, United States
Lumberton, North Carolina, United States
Camp Hill, Pennsylvania, United States
Lancaster, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Wyomissing, Pennsylvania, United States
Sioux Falls, South Dakota, United States
Jackson, Tennessee, United States
Allen, Texas, United States
Dallas, Texas, United States
El Paso, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Chesterfield, Virginia, United States
Winchester, Virginia, United States
Seattle, Washington, United States
Spokane, Washington, United States
Madison, Wisconsin, United States
Milwaukee, Wisconsin, United States
Granadero Baigorria, Santa Fe, Argentina
Concord, New South Wales, Australia
Braunau, Austria
Graz, Austria
Salzburg, Austria
Aalst, Belgium
Edegem, Belgium
Banja Luka, Bosnia And Herzegovina
Sarajevo, Bosnia And Herzegovina
Belo Horizonte, Minas Gerais, Brazil
Aracaju, Brazil
Belo Horizonte/Mg, Brazil
Goiânia/Go, Brazil
Marília/Sp, Brazil
Porto Alegre/Rs, Brazil
Recife/Pe, Brazil
Ribeirão Preto/Sp, Brazil
Rio De Janeiro, Brazil
São Paulo/Sp, Brazil
Burgas, Bulgaria
Lom, Bulgaria
Sandanski, Bulgaria
Sevlievo, Bulgaria
Sofia, Bulgaria
Veliko Tarnovo, Bulgaria
Calgary, Alberta, Canada
North Vancouver, British Columbia, Canada
Winnipeg, Manitoba, Canada
Cambridge, Ontario, Canada
Hamilton, Ontario, Canada
Sudbury, Ontario, Canada
Toronto, Ontario, Canada
Winchester, Ontario, Canada
Montréal, Quebec, Canada
Sherbrooke, Quebec, Canada
St. Jean Sur Richelieu, Quebec, Canada
Terrebonne, Quebec, Canada
Trois Rivières, Quebec, Canada
Guangzhou, Guangdong, China
Anhui/Huainan, China
Changsha, China
Ha Erbin, China
Shanghai, China
Manizales, Caldas, Colombia
Barranquilla, Colombia
Medellin, Colombia
Zagreb, Grad Zagreb, Croatia
Zagreb, Croatia
Zagreb, Croatia
Plzen Lochotín, Czechia
Praha 1, Czechia
Praha 2, Czechia
Trutnov, Czechia
Uherske Hradiste, Czechia
Herlev, Region Hovedstaden, Denmark
Hus, Finland
Montpellier, France
Paris, France
Toulouse, France
Berlin, Germany
Bremen, Germany
Dortmund, Germany
Freiburg, Germany
Giessen, Germany
Hassloch, Germany
Papenburg, Germany
Athens, Attiki, Greece
Heraklion, Crete, Greece
Athens, Greece
Athens, Greece
Chaidari, Athens, Greece
Rio Patras, Greece
Thessaloniki, Greece
Thessaloniki, Greece
Pécs, Baranya Megye, Hungary
Orosháza, Békés Megye, Hungary
Kaposvár, Somogy Megye, Hungary
Vijaywada, Andhra Pradesh, India
Ahmedabad, Gujarat, India
Bengaluru, Karnataka, India
Nagpur, Maharashtra, India
Mohali, Punjab, India
Bikaner, Rajasthan, India
Jodhpur, Rajasthan, India
Bengaluru, India
Karnataka, India
New Delhi, India
New Delhi, India
Dublin, Ireland
Dublin, Ireland
Mahon, Cork, Ireland
Haifa, Israel
Petah Tikva, Israel
Zrifin, Israel
Benevento, Bn, Italy
Brescia, Bs, Italy
Caserta, Ce, Italy
Genova, Ge, Italy
Perugia, Pg, Italy
Rivoli, To, Italy
Torino, To, Italy
Verona, Vr, Italy
Napoli, Italy
Yokohama, Kanagawa, Japan
Fukuoka, Japan
Fukuoka, Japan
Gifu, Japan
Himeji Shi, Hyogo, Japan
Hokkaido, Japan
Hyogo, Japan
Imabari Shi, Ehime, Japan
Ishikawa, Japan
Kagawa, Japan
Kagoshima, Japan
Kanagawa, Japan
Kanagawa, Japan
Kanagawa, Japan
Kishiwada Shi, Osaka, Japan
Kitakyushu Shi, Fukuoka, Japan
Kyoto, Japan
Mie, Japan
Miyagi, Japan
Miyagi, Japan
Miyagi, Japan
Nagasaki, Japan
Okayama, Japan
Okayama, Japan
Osaka, Japan
Osaka, Japan
Osaka, Japan
Saga, Japan
Shizuoka, Japan
Tokyo, Japan
Tottori, Japan
Toyama, Japan
Yamaguchi, Japan
Yamaguchi, Japan
Riga, Latvia
Siauliai, Lithuania
Aguascalientes, Ags, Mexico
San Nicolas De Los Garza, Nl, Mexico
Santiago De Querétaro, Qro., Querétaro, Mexico
Xalapa, Veracruz, Mexico
Mexico City, Mexico
Dordrecht, Netherlands
Heerlen, Netherlands
Skopje, North Macedonia
Skopje, North Macedonia
Oslo, Norway
Oslo, Norway
Stavanger, Norway
Torun, Kuyavian Pomeranian Voivodeship, Poland
Chrzanów, Małopolskie, Poland
Cracow, Małopolskie, Poland
Bialystok, Podlaskie Voivodeship, Poland
Katowice, Silesian Voivodeship, Poland
Lodz, Poland
Przemysl, Poland
Sztum, Poland
Zgierz, łódź Voivodeship, Poland
Dąbrowa Górnicza, śląskie, Poland
Tychy, śląskie, Poland
Tirgu Mures, Targu Mures, Romania
Bucuresti, Romania
Timișoara, Romania
Brezno, Banskobystricky Kraj, Slovakia
Svidnik, Presovsky Kraj, Slovakia
Bratislava, Slovakia
Kosice, Slovakia
Nitra, Slovakia
Trnava, Slovakia
Zilina, Slovakia
Celje, Slovenia
Ljubljana, Slovenia
Maribor, Slovenia
Johannesburg, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Durban, Kwwazulu Natal, South Africa
Istanbul, Turkey
Airdrie, Lanarkshire, United Kingdom
Tooting, London, United Kingdom
East Kilbride, South Lanarkshire, United Kingdom
Dorest, United Kingdom
Bragança Paulista, São Paulo, Brazil
Frankfurt Am Main, Germany
Piraeus, Greece
Ahmedabad, Gujarat, India
Grosseto, Italy
Krosno, Poland
Santa Fe, Argentina
Belo Horizonte, Minas Gerais, Brazil
Leiria, Portugal
Mar Del Plata, Buenos Aires, Argentina
Midrand, Gauteng, South Africa
Baja, Bács Kiskun Vármegye, Hungary
Miami, Florida, United States
Campinas, Sao Paulo, Brazil
Cali, Colombia
Kalamata, Greece
Kwadukuza, Kwazulu Natal, South Africa
Homburg, Germany
Wroclaw, Dolnoslaskie, Poland
Cambridge, Ontario, Canada
Dortmund, Germany
Rivoli, To, Italy
Milano, Italy
Tokyo, Japan
Amsterdam, Netherlands
Martin, Slovakia
Toulon, France
Vandoeuvre Les Nancy, France
Valencia, Spain
Medellin, Antioquia, Colombia
Budapest, Hungary
Bielefeld, Germany
Ampelokipoi/Athens, Greece
Hadera, Israel
Kluczbork, Poland
İstanbul, Turkey
Larissa, Greece
Uwajima Shi, Ehime, Japan
Coral Gables, Florida, United States
Amarillo, Texas, United States
Caba, Buenos Aires, Argentina, Argentina
Corrientes, Buenos Aires, Argentina
Cali, Valle Del Cauca, Colombia
Mexico, Mexico
Chiang Rai, Thailand
Phitsanulok, Thailand
Samutsakhon, Thailand
Thessaloniki, Greece
Porto, Portugal
Campinas, Sao Paulo, Brazil
Santa Fé, Santa Fe, Argentina
Osijek, Croatia
Split, Croatia
Sofia, Bulgaria
Skopje, North Macedonia
Bucharest, Romania
Targu Mures, Romania
Würzburg, Germany
Leipzig, Germany
Satu Mare, Romania
Pleven, Bulgaria
Chelmer, Queensland, Australia
Göttingen, Germany
Perugia, Pg, Italy
Mexico, Mexico
Dresden, Germany
Campina Grande Do Sul, Paraná, Brazil
Dortmund, Germany
Arlington Heights, Illinois, United States
Knoxville, Tennessee, United States
Aarhus N, Denmark
Aachen, Germany
Włocławek, Kujawsko Pomorskie, Poland
Wien, Austria
Bialystok, Podlaskie, Poland
Terrebonne, Quebec, Canada
Santa Maria Da Feira, Portugal
Setubal, Portugal
Jena, Germany
Berlin, Germany
Leipzig, Germany
Katowice, Poland
Lodz, Lodzkie, Poland
Milwaukee, Wisconsin, United States
Burgas, Bulgaria
Frankfurt Am Main, Germany
Pleven, Bulgaria
Mainz, Germany
Tychy, Poland
Setubal, Portugal
Houston, Texas, United States
Liverpool, New South Wales, Australia
Longueuil, Quebec, Canada
Wuhan, Hubei, China
Changchun, Jilin, China
Shenyang, Liaoning, China
Xi'an, Shaanxi, China
Shanghai, Shanghai, China
Lishui, Zhejiang, China
Wenzhou, Zhejiang, China
Anhui/Huainan, China
Ha Erbin, China
Xi'an, China
ćepin, Croatia
Brno, Czechia
Policka, Czechia
Praha 1, Czechia
Tabor, Czechia
Giessen, Germany
Kifisia, Greece
Beer Yaakov, Israel
Grobina, Dienvidkurzemes Novads, Latvia
Riga, Latvia
Kaunas, Lithuania
Katowice, Poland
Katowice, Poland
Katowice, Poland
Lublin, Poland
Miechów, Poland
Warszawa, Poland
Warszawa, Poland
świnoujście, Poland
żarów, Poland
Malacky, Slovakia
Madrid, Spain
Chios, Greece
Athens, Greece
Lisboa, Portugal
Athens, Attiki, Greece
Jelgava, Latvia
Barranquilla, Atlántico, Colombia
Guarda, Portugal
Athens, Greece
Athens, Greece
Chaidari, Athens, Greece
Larissa, Greece
łask, Poland
Ampelokipoi/Athens, Greece
Beer Yaakov, Israel
Leiria, Portugal
Braunau, Austria
Curitiba, Pr, Brazil
Tatuí, São Paulo, Brazil
Kardzhali, Bulgaria
Kyustendil, Bulgaria
Sliven, Bulgaria
Sofia, Bulgaria
Shantou, Guangdong, China
Harbin, Heilongjiang, China
Xuzhou, Jiangsu, China
Chongqing, China
Bogotá, Colombia
Bogotá, Colombia
Heraklion, Crete, Greece
Pylea, Thessaloniki, Greece
Rio Patras, Greece
Baja, Hungary
Balatonfüred, Hungary
Budapest, Hungary
Miskolc, Hungary
Treviso, Veneto, Italy
Bari, Italy
Tokyo, Japan
Grobina, Dienvidkurzemes Novads, Latvia
Riga, Latvia
Riga, Latvia
Riga, Latvia
Riga, Latvia
Kaunas, Lithuania
Kaunas, Lithuania
Klaipeda, Lithuania
Siauliai, Lithuania
Vilnius, Lithuania
Grodzisk Mazowiecki, Mazowieckie, Poland
Gdynia, Pomorskie, Poland
Ruda Slaska, Silesian Voivodeship, Poland
Guilhufe Penafiel, Portugal
Lisboa, Portugal
Lisbon, Portugal
Santa Maria Da Feira, Portugal
Celje, Slovenia
Ljubljana, Slovenia
Maribor, Slovenia
Ekurhuleni, South Africa
Mianyang, Sichuan, China
Shijiazhuang, Hebei, China
Nanchang, Jiangxi, China
Jining, Shandong, China
Chía, Cundinamarca, Colombia
Lisbon, Portugal
Mossel Bay, Western Cape, South Africa
Beijing, Beijing, China
Figueira Da Foz, Portugal
Belgrade, Serbia
Sofia, Bulgaria
Wuhan, Hubei, China
Changchun, Jilin, China
čakovec., Croatia
Berlin, Germany
Bochum, Germany
Dresden, Germany
Rotenburg A.D. Fulda, Germany
Iraklio, Greece
Mitilini, Greece
Bucheon Si, Gyeonggi Do, Korea, Republic Of
Ostrow Wielkopolski, Poland
Rzeszow, Poland
Rzeszów, Poland
Bucuresti, Romania
Leskovac, Serbia
Uzice, Serbia
Piestany, Slovakia
Las Palmas De Gran Canaria, Spain
Hat Yai Songkla, Songkla, Thailand
Airdrie, Lanarkshire, United Kingdom
North Miami Beach, Florida, United States
Huainan, Anhui, China
Osaka, Japan
Gliwice, Poland
Timisoara, Romania
Taoyuan, Taiwan
Bangkok, Thailand
Chiang Mai, Thailand
Barranquilla, Colombia
Ciudad De Mexico, Mexico
Monterrey, Mexico
Szeged, Hungary
Komárom, Hungary
Cidade Nova Votuporanga, Brazil
Békéscsaba, Hungary
Campina Grande Do Sul, Brazil
Bragança Paulista, Brazil
Tatuí, Brazil
Orosháza, Hungary
Santiago De Querétaro, Qro., Mexico
Cracow, Poland
Zgierz, Poland
Dąbrowa Górnicza, Poland
Benoni, Gauteng, South Africa
Dresden, Germany
Freiburg, Germany
Jerusalem, Israel
Petah Tikva, Israel
Tel Aviv, Israel
Tel Hashomer, Israel
Braga, Portugal
Hoppers Crossing, Victoria, Australia
Huainan, Anhui, China
Lanzhou, Gansu, China
Wenzhou, Zhejiang, China
Zagreb, Croatia
čepin, Croatia
Aachen, Germany
Bielefeld, Germany
Bochum, Germany
Dortmund, Germany
Giessen, Germany
Göttingen, Germany
Hamburg, Germany
Homburg, Germany
Jena, Germany
Rotenburg A.D. Fulda, Germany
Beer Yaakov, Israel
Hadera, Israel
Haifa, Israel
Rehovot, Israel
Casale Monferrato, Al, Italy
Benevento, Bn, Italy
Roma, Rm, Italy
Bari, Italy
Napoli, Italy
Novara, Italy
Imabari Shi, Ehime, Japan
Kitakyushu Shi, Fukuoka, Japan
Morioka Shi, Iwate, Japan
Okayama, Japan
Osaka, Japan
Tokyo, Japan
Yamaguchi, Japan
Bangkok, Thailand
Phitsanulok, Thailand
Chichester, West Sussex, United Kingdom
Craigavon, United Kingdom
Oldham, United Kingdom
Patients applied
Trial Officials
Clinical Transparency (dept. 2834)
Study Director
Novo Nordisk A/S
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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