The Role of NLR in the Diagnosis and Prognosis of Sepsis

Launched by WUHAN UNION HOSPITAL, CHINA · Nov 22, 2022

Keywords

ClinConnect Summary

Sepsis is defined as a life-threatening organ dysfunction caused by the host's malfunctioning response to infection, which has become one of the major problems in the world's public health. The development of effective biomarkers for the diagnosis of sepsis is undoubtedly helpful for us to timely and accurately understand the diagnosis, progression, and prognosis of sepsis.

The neutrophil-to-lymphocyte ratio (NLR), as an inflammatory indicator, is inexpensive and easily accessible parameter and could be widely used. In severe infectious diseases, particularly in sepsis, a substantial incre...

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Eligibility criteria

• Inclusion Criteria:
• • 1.Patients with sepsis
• • 2.ICU stay time ≥3 days;
• Exclusion Criteria:
• • 1. History of solid organ or bone marrow transplantation;
• • 2. Diseases that may affect immune-related indicators, such as autoimmune diseases such as rheumatoid arthritis and SLE, or hematological malignancies such as leukemia and lymphoma;
• • 3. Have received radiotherapy or chemotherapy within the past 30 days, or have received immunosuppressive drugs (tripterygium, mycophenolate, cyclophosphamide, FK506, etc.), or have received continuous treatment with more than 10mg of prednisolone/day (or the same dose of other hormones);
• • 4. Pregnancy or lactation;c