The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke

Launched by UNIVERSITY OF EDINBURGH · Nov 23, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the role of blood clots, known as thrombus, in causing certain types of strokes, particularly ischaemic stroke. Ischaemic strokes happen when a blood vessel in the brain gets blocked, often by a thrombus. The researchers are using a special imaging technique with a new substance called 18F-GP1 that can specifically identify these clots. By using this imaging, they hope to better understand where the clots come from and how they contribute to different types of strokes, including those that don't have a clear cause.

To participate in this trial, individuals must be at least 18 years old and have been diagnosed with an acute ischaemic stroke within the past 21 days. The study is open to all genders. Participants will undergo imaging scans to help identify thrombus in their system. It's important to note that some individuals may not be eligible due to certain health conditions or if they have had a different type of stroke, like a hemorrhagic stroke. This trial aims to improve our understanding of strokes and may help in developing better treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Males and females ≥18 years old
• • Diagnoses of acute ischaemic stroke (within 21 days of symptom onset) as per American Heart and Stroke Association guidelines
• Exclusion Criteria:
• • Inability or unwillingness to provide informed written consent (ie lack capacity)
• • Inability to undergo the scanning protocol including ability to transfer onto the scanner
• • Women of child- bearing potential in whom pregnancy cannot be excluded
• • Contraindication to PET-CT scanning including estimated glomerular filtration rate \<30 mL/min/1.73 m2
• • Participation in the study would result in a delay to carotid endarterectomy surgery
• • Known allergy to iodinated contrast or radiotracer
• • Severe or significant comorbidity precluding ability to complete study procedures.
• • Haemorrhagic stroke
• • Contra-indication to Magnetic Resonance imaging for those patients requiring a MRI Head