The Value of Repeated BIOMarker Measurements During an SBT to Predict EXtubation Failure in ICU Patients

Launched by HENRIK ENDEMAN · Nov 24, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how measuring certain biomarkers (substances in the body that can indicate health conditions) during a specific test called a Spontaneous Breathing Trial (SBT) can help predict whether patients in the Intensive Care Unit (ICU) will be able to successfully breathe without a ventilator after being on mechanical ventilation. The goal is to improve patient care by identifying those who might struggle to breathe on their own, allowing for better planning and treatment.

To participate in this trial, individuals must be at least 18 years old and have been on a ventilator for more than 48 hours. They should also meet specific criteria that suggest they are ready to try breathing on their own again. Participants will undergo biomarker testing during the SBT and will need to provide consent, either personally or through a legal representative. It’s important to note that patients with certain complications or serious illnesses may not be eligible. Overall, this study aims to enhance the safety and effectiveness of weaning patients off mechanical ventilation in the ICU.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged ≥18 years
• • Mechanically ventilated for more than 48 hours
• • Fulfilling readiness-to wean criteria
• • Written informed consent from the patient or his/her legal representative
• Exclusion Criteria:
• • Patients with risk factors for laryngeal oedema and a negative cuff leak test (indicating upper airway obstruction with need for steroid treatment)
• • Planned replacement of the endotracheal tube for a tracheostomy
• • Terminal illness

Trial Officials