Monocyte Chemoattractant Protein-1 in Psoriatic Arthritis Patients

Launched by ASSIUT UNIVERSITY · Nov 25, 2022

Keywords

ClinConnect Summary

Psoriatic arthritis (PSA) is an autoimmune disease arising from the interply between proinflamatory cytokines

\[1\]and external stimuli in genetically predisposed individuals.\[2\]

* The disease is chronic and affects the peripheral joints and may include axial skeleton with or without extrarticular manifestations.\[3\]
* Abnormal activation of the innate and adaptive immune systems contributes to chronic disease processes in both psoriasis and PSA .\[4\] The skin and the joints exhibit a prominent lymphocytic infiltrate consisting of activated CD4+ and CD8+ T cells as well as an increase...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • PsA patients (age ≥ 18years) who fulfilled the CASPAR classification criteria\[15\]for psoriatic arthritis
• Exclusion Criteria:
• • PsA patients with
• • 1. infection.
• • 2. bone marrow disorders.
• • 3. other autoimmune diseases.
• • 4. diabetes.
• • 5. hypertention .
• • 6. hyperlipidemia.
• • 7. liver diseases.
• • 8. renal diseases.

Trial Officials