FAZA PETMRI Kidney Graft Fibrosis Study

Launched by UNIVERSITY HEALTH NETWORK, TORONTO · Nov 25, 2022

Keywords

ClinConnect Summary

No description provided

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥18 years
• • 2. Evidence of impaired kidney graft function based on elevated serum creatinine from baseline and/ or evidence of significant proteinuria and/or donor specific antibodies
• • 3. A negative urine or serum pregnancy test within the three week interval immediately prior to imaging, in women of child-bearing age
• • 4. Ability to provide written informed consent to participate in the study (for both patients groups - with and without impaired kidney graft function)
• 5. Two study groups:
• • Evidence of impaired kidney graft function based on elevated serum creatinine from baseline and/ or evidence of significant proteinuria and/or donor specific antibodies and scheduled for a kidney graft biopsy.
• • comparison (control) group with stable kidney graft function, matched for graft/recipient age, sex and comorbidities
• Exclusion Criteria:
• • 1. Contraindication for MR as per current institutional guidelines
• • 2. Inability to lie supine for at least 30 minutes
• • 3. Any patient who is pregnant or breastfeeding
• • 4. Any patient unable or unwilling to provide informed consent

Trial Officials