Trials
Search / Trial NCT05638542

Comparison of Expression of Carcinogenesis-related Molecular Markers in the Patients With Colon Cancer and Polyp

Launched by SEOUL NATIONAL UNIVERSITY BUNDANG HOSPITAL · Nov 27, 2022

Trial Information

Current as of February 05, 2025

Active, not recruiting

Keywords

Carcinogenesis Sex Difference Tumor Location

ClinConnect Summary

The chromosomal instability (CIN) pathway, the CpG island methylator phenotype (CIMP) pathway and the microsatellite instability (MSI) pathway are three major carcinogenesis pathways to colorectal cancer (CRC). In this study, the investigators aimed to investigate distinctive molecular features of carcinogenesis pathways among healthy control, colorectal adenoma, and CRC and compare their molecular progression according to patients' sex and tumor location as well as disease stage.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Control group: subjects with no evidence of colorectal adenoma or colorectal cancer
  • Colorectal adenoma group: Patients with colorectal adenomas greater than or equal to 10 mm in diameter according to the endoscopic presentation as well as histological validation of colorectal adenoma.
  • Colorectal cancer group: Patients whose biopsy specimen is histologically confirmed as colorectal adenocarcinoma
  • Exclusion Criteria:
  • Subjects age under 18 years
  • Previous history of colorectal neoplasms
  • Patients with high bleeding risk or patients who must maintain anti-coagulant or anti-platelet agents
  • Denial to participate in this study

Trial Officials

Nayoung Kim, M.D., Ph.D

Study Chair

Seoul National University Bundang Hospital

About Seoul National University Bundang Hospital

Seoul National University Bundang Hospital is a leading academic medical center located in South Korea, renowned for its commitment to innovative research and excellence in patient care. As a sponsor of clinical trials, the hospital leverages its extensive expertise in various medical fields, employing cutting-edge technologies and methodologies to advance healthcare solutions. With a multidisciplinary team of skilled researchers and clinicians, the hospital aims to enhance clinical outcomes through rigorous investigation and collaboration, contributing significantly to the global medical community and improving patient lives.

Locations

Seongnam Si, Gyeonggi Do, Korea, Republic Of

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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